LOCUS 91284_PB_tet_PHS 14520 bp ds-DNA circular 25-JUL-2013 DEFINITION . ACCESSION VERSION SOURCE . ORGANISM . COMMENT Insert from S:/genbank format/90962 pORF-DNMT3B(FLJ09073AAAN).ape414 to 2771 COMMENT Backbone from S:/genbank format/90946 PB-tet-PH-lox66FRT2.str 6253to 4570 COMMENT ApEinfo:methylated:1 FEATURES Location/Qualifiers source 4605..6917 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="20" /map="20q11.2" /label=source:Homo sapiens /ApEinfo_fwdcolor=#ffffff /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1205..1459 /label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4747..4808 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=4 /label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3331..3678 /label=polyA /ApEinfo_fwdcolor=#ff8080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5259..5417 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=8 /label=DNMT3B(1) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4563..4570 /label=AttR1 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5797..5841 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=13 /label=DNMT3B(2) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1460..1711 /label=mouse PGK promoter(1) /ApEinfo_label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 6219..6303 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=17 /label=DNMT3B(3) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 7652..7720 /label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 11443..11749 /label=pA /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(13532..14191) /label=AmpR /ApEinfo_fwdcolor=yellow /ApEinfo_revcolor=yellow /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 6690..6775 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=21 /label=DNMT3B(4) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(463..531) /label=LacZ alpha(1) /ApEinfo_label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 gene 4605..6917 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /note="DNA (cytosine-5-)-methyltransferase 3 beta" /db_xref="GeneID:1789" /db_xref="HGNC:2979" /db_xref="HPRD:04209" /db_xref="MIM:602900" /label=DNMT3B(5) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6975..7498 /label=IRES /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 707..941 /label=PB 3'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4809..4910 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=5 /label=DNMT3B(6) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5418..5525 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=9 /label=DNMT3B(7) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 11867..12137 /label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 12138..12179 /label=PB 5'LTR(1) /ApEinfo_label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5842..5921 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=14 /label=DNMT3B(8) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4446..4551 /label=mCMV promoter /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 6304..6449 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=18 /label=DNMT3B(9) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4160..4437 /label=8xTetO2 element /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 6776..6917 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=24 /label=DNMT3B(10) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(12327..12346) /label=T3 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4605..4746 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=3 /label=DNMT3B(11) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3685..3926 /label=chicken 5'-HS4 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4911..5036 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=6 /label=DNMT3B(12) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 602..619 /label=M13-fwd /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5526..5670 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=10 /label=DNMT3B(13) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 618..645 /label=T7 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5922..6034 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=15 /label=DNMT3B(14) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1732..2328 /label=Pac /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 6450..6540 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=19 /label=DNMT3B(15) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 4605..6917 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /EC_number="2.1.1.37" /note="isoform 3 is encoded by transcript variant 3; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; DNA (cytosine-5)-methyltransferase 3B" /codon_start=1 /product="DNA (cytosine-5)-methyltransferase 3B isoform 3" /protein_id="NP_787045.1" /db_xref="GI:28559063" /db_xref="CCDS:CCDS13207.1" /db_xref="GeneID:1789" /db_xref="HGNC:2979" /db_xref="HPRD:04209" /db_xref="MIM:602900" /translation="MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTP EIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPA VRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPS PPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQ DGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADK LVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLE WAHGGFKPTGIEGLKPNNTQPENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGD EDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYD DDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCL PQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIAT GYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDL VIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAM KVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRIFGFPVHYTDVSNMGR GARQKLLGRSWSVPVIRHLFAPLKDYFACE" /label=DNA (cytosine-5)-methyltransferase 3B isoform 3 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature complement(6929..6943) /label=AttR2 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(12364..12384) /label=M13-rev /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5037..5258 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=7 /label=DNMT3B(16) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 7500..11442 /label=b-geo /ApEinfo_fwdcolor=#800000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(12752..13434) /label=ColE1 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5671..5796 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=12 /label=DNMT3B(17) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(135..441) /label=F1 ori /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 6035..6218 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=16 /label=DNMT3B(18) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(3..458) /label=M13 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 6541..6689 /gene="DNMT3B" /gene_synonym="ICF; ICF1; M.HsaIIIB" /inference="alignment:Splign:1.39.8" /number=20 /label=DNMT3B(19) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 2335..3330 /label=DeltaTK /ApEinfo_fwdcolor=#0000ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4605..6917 /label=DNMT3B(20) /ApEinfo_label=DNMT3B /ApEinfo_fwdcolor=#ff00ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 7563..10588 /label=LacZ /ApEinfo_fwdcolor=#00ffff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_binding complement(12390..12412) /label=LacO /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 ORIGIN 1 GGAAATTGTA AACGTTAATA TTTTGTTAAA ATTCGCGTTA AATTTTTGTT AAATCAGCTC 61 ATTTTTTAAC CAATAGGCCG AAATCGGCAA AATCCCTTAT AAATCAAAAG AATAGACCGA 121 GATAGGGTTG AGTGTTGTTC CAGTTTGGAA CAAGAGTCCA CTATTAAAGA ACGTGGACTC 181 CAACGTCAAA GGGCGAAAAA CCGTCTATCA GGGCGATGGC CCACTACGTG AACCATCACC 241 CTAATCAAGT TTTTTGGGGT CGAGGTGCCG TAAAGCACTA AATCGGAACC CTAAAGGGAG 301 CCCCCGATTT AGAGCTTGAC GGGGAAAGCC GGCGAACGTG GCGAGAAAGG AAGGGAAGAA 361 AGCGAAAGGA GCGGGCGCTA GGGCGCTGGC AAGTGTAGCG GTCACGCTGC GCGTAACCAC 421 CACACCCGCC GCGCTTAATG CGCCGCTACA GGGCGCGTCG CGCCATTCGC CATTCAGGCT 481 GCGCAACTGT TGGGAAGGGC GATCGGTGCG GGCCTCTTCG CTATTACGCC AGCTGGCGAA 541 AGGGGGATGT GCTGCAAGGC GATTAAGTTG GGTAACGCCA GGGTTTTCCC AGTCACGACG 601 TTGTAAAACG ACGGCCAGTG AATTGTAATA CGACTCACTA TAGGGCGAAT TGGAGCTCGG 661 TATTCACGAC AGCAGGCTGA ATAATAAAAA AATTAGAAAC TATTATttaa ccctagaaag 721 ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc atgtgtttta 781 tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt tattatattt 841 acacttacat actaataata aattcaacaa acaatttatt tatgtttatt tatttattaa 901 aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttaAA CATTCTCTCT 961 TTTACAAAAA TAAACTTATT TTGTACTTTA AAAACAGTCA TGTTGTATTA TAAAATAAGT 1021 AATTAGCTTA ACCTATACAT AATAGAAACA AATTATACTT ATTAGTCAGT CAGAAACAAC 1081 TTTGGCACAT ATCAATATTA TGCTCTCGTT ACTGGCGAAA GGGGGATGTG CTGCAAGGCG 1141 ATTAAGTTGG GTAACGCCAG GGTTTTCCCA GTCACGACGT TGTAAAACGA CGGCCAGTGA 1201 ATTCtaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc 1261 cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac 1321 cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc 1381 cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga 1441 agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt 1501 aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct 1561 gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg 1621 aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt 1681 ctcctcttcc tcatctccgg gcctttcgac cGATCATCAA GCTTGATCCT Catgaccgag 1741 tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccAgggccgt acgcaccctc 1801 gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgaTccgga ccgccacatc 1861 gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag 1921 gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa 1981 gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg 2041 gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg 2101 ttcctggcca ccgtcggcgt ctcgcccgac caccagggca agggtctggg cagcgccgtc 2161 gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacctcc 2221 gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag 2281 Gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgccgg atccATGCCC 2341 ACGCTACTGC GGGTTTATAT AGACGGTCCC CACGGGATGG GGAAAACCAC CACCACGCAA 2401 CTGCTGGTGG CCCTGGGTTC GCGCGACGAT ATCGTCTACG TACCCGAGCC GATGACTTAC 2461 TGGCGGGTGc TGGGGGCTTC CGAGACAATC GCGAACATCT ACACCACACA ACACCGCCTC 2521 GACCAGGGTG AGATATCGGC CGGGGACGCG GCGGTGGTAA TGACAAGCGC CCAGATAACA 2581 ATGGGCATGC CTTATGCCGT GACCGACGCC GTTCTGGCTC CTCATATCGG GGGGGAGGCT 2641 GGGAGCTCAC ATGCCCCGCC CCCGGCCCTC ACCCTCATCT TCGACCGCCA TCCCATCGCC 2701 GCCCTCCTGT GCTACCCGGC CGCGCGgTAC CTTATGGGCA GCATGACCCC CCAGGCCGTG 2761 CTGGCGTTCG TGGCCCTCAT CCCGCCGACC TTGCCCGGCA CcAACATCGT GcTTGGGGCC 2821 CTTCCGGAGG ACAGACACAT CGACCGCCTG GCCAAACGCC AGCGCCCCGG CGAGCGGCTg 2881 GACCTGGCTA TGCTGGCtGC GATTCGCCGC GTTTAcGGGC TaCTTGCCAA TACGGTGCGG 2941 TATCTGCAGt GCGGCGGGTC GTGGCGGGAG GAcTGGGGAC AGCTTTCGGG GaCGGCCGTG 3001 CCGCCCCAGG GTGCCGAGCC CCAGAGCAAC GCGGGCCCAC GACCCCATAT CGGGGACACG 3061 TTATTTACCC TGTTTCGGGC CCCCGAGTTG CTGGCCCCCA ACGGCGACCT GTATAACGTG 3121 TTTGCCTGGG CcTTGGACGT CTTGGCCAAA CGCCTCCGTT CCATGCACGT CTTTATCCTG 3181 GATTACGACC AATCGCCCGC CGGCTGCCGG GACGCCCTGC TGCAACTTAC CTCCGGGATG 3241 GTCCAGACCC ACGTCACCAC CCCCGGCTCC ATACCGACGA TATGCGACCT GGCGCGCACG 3301 TTTGCCCGGG AGATGGGGGA GGCTAACTGA gctctagctt atcgactcgc cgatagtgga 3361 aaccgacgcc ccagcactcg tccgagggca aaggaatagt cgagaaattg atgatctatt 3421 aaacaataaa gatgtccaca tggaagtttt tcctgtcata ctttgttaag aagggtgaga 3481 acagagtacc tacattttga atggaaggat tggagctacg ggggtggggg tggggtggga 3541 ttagataaat gcctgctctt tactgaaggc tctttactat tgctttatga taatgtttca 3601 tagttggata tcataattta aacaagcaaa accaaattaa gggccagctc attcctccca 3661 ctcatgatct atagatccTc tagaGAGCTC ACGGGGACAG CCCCCCCCCA AAGCCCCCAG 3721 GGATGTAATT ACGTCCCTCC CCCGCTAGGG GGCAGCAGCG AGCCGCCCGG GGCTCCGCTC 3781 CGGTCCGGCG CTCCCCCCGC ATCCCCGAGC CGGCAGCGTG CGGGGACAGC CCGGGCACGG 3841 GGAAGGTGGC ACGGGATCGC TTTCCTCTGA ACGCTTCTCG CTGCTCTTTG AGCCTGCAGA 3901 CACCTGGGGG ATACGGGGAA AAAGCTgtcg aCCTGCAGGC ATGCAAGCTT GGCGTAATCA 3961 TGGTCATAGC TGTTTCCTGT GTGAAATTGT TATCCGCTCA CAATTCCACA CAACATACGA 4021 GCCGGAAGCA TAAAGTGTAA AGCCTGGGGT GCCTAATGAG TGAGCTAACT CACATTAATT 4081 GCGTTGCGCT CACTGCCCGC TTTCCAGTCG GGAAACCTGT CGTGCCAGTA ACTCGAGGGA 4141 TCCAAGCTgg CCgcACGTCT CCCTATCAGT GATAGAGAAG TCGACACGTC TCGAGCTCCC 4201 TATCAGTGAT AGAGAAGGTA CGTCTAGAAC GTCTCCCTAT CAGTGATAGA GAAGTCGACA 4261 CGTCTCGAGC TCCCTATCAG TGATAGAGAA GGTACGTCTA GAACGTCTCC CTATCAGTGA 4321 TAGAGAAGTC GACACGTCTC GAGCTCCCTA TCAGTGATAG AGAAGGTACG TCTAGAACGT 4381 CTCCCTATCA GTGATAGAGA AGTCGACACG TCTCGAGCTC CCTATCAGTG ATAGAGAAGG 4441 TACCCCCTAT ATAAGCAGAG CTCGTTTAGT GAACCGTCAG ATCGCCTGGA GACGCCATCC 4501 ACGCTGTTTT GACCTCCATA GAAGACACCG GGACCGATCC AGCCTCCGCG GTGGCGGCCA 4561 TCACAAGTTT GTACAAAAAA GCAGGCTTCG AAGGAGATAG AACCatgaag ggagacacca 4621 ggcatctcaa tggagaggag gacgccggcg ggagggaaga ctcgatcctc gtcaacgggg 4681 cctgcagcga ccagtcctcc gactcgcccc caatcctgga ggctatccgc accccggaga 4741 tcagaggccg aagatcaagc tcgcgactct ccaagaggga ggtgtccagt ctgctaagct 4801 acacacagga cttgacaggc gatggcgacg gggaagatgg ggatggctct gacaccccag 4861 tcatgccaaa gctcttccgg gaaaccagga ctcgttcaga aagcccagct gtccgaactc 4921 gaaataacaa cagtgtctcc agccgggaga ggcacaggcc ttccccacgt tccacccgag 4981 gccggcaggg ccgcaaccat gtggacgagt cccccgtgga gttcccggct accaggtccc 5041 tgagacggcg ggcaacagca tcggcaggaa cgccatggcc gtcccctccc agctcttacc 5101 ttaccatcga cctcacagac gacacagagg acacacatgg gacgccccag agcagcagta 5161 ccccctacgc ccgcctagcc caggacagcc agcagggggg catggagtcc ccgcaggtgg 5221 aggcagacag tggagatgga gacagttcag agtatcagga tgggaaggag tttggaatag 5281 gggacctcgt gtggggaaag atcaagggct tctcctggtg gcccgccatg gtggtgtctt 5341 ggaaggccac ctccaagcga caggctatgt ctggcatgcg gtgggtccag tggtttggcg 5401 atggcaagtt ctccgaggtc tctgcagaca aactggtggc actggggctg ttcagccagc 5461 actttaattt ggccaccttc aataagctcg tctcctatcg aaaagccatg taccatgctc 5521 tggagaaagc tagggtgcga gctggcaaga ccttccccag cagccctgga gactcattgg 5581 aggaccagct gaagcccatg ttggagtggg cccacggggg cttcaagccc actgggatcg 5641 agggcctcaa acccaacaac acgcaaccag agaacaagac tcgaagacgc acagctgacg 5701 actcagccac ctctgactac tgccccgcac ccaagcgcct caagacaaat tgctataaca 5761 acggcaaaga ccgaggggat gaagatcaga gccgagaaca aatggcttca gatgttgcca 5821 acaacaagag cagcctggaa gatggctgtt tgtcttgtgg caggaaaaac cccgtgtcct 5881 tccaccctct ctttgagggg gggctctgtc agacatgccg ggatcgcttc cttgagctgt 5941 tttacatgta tgatgacgat ggctatcagt cttactgcac tgtgtgctgc gagggccgag 6001 agctgctgct ttgcagcaac acgagctgct gccggtgttt ctgtgtggag tgcctggagg 6061 tgctggtggg cacaggcaca gcggccgagg ccaagcttca ggagccctgg agctgttaca 6121 tgtgtctccc gcagcgctgt catggcgtcc tgcggcgccg gaaggactgg aacgtgcgcc 6181 tgcaggcctt cttcaccagt gacacggggc ttgaatatga agcccccaag ctgtaccctg 6241 ccattcccgc agcccgaagg cggcccattc gagtcctgtc attgtttgat ggcatcgcga 6301 caggctacct agtcctcaaa gagttgggca taaaggtagg aaagtacgtc gcttctgaag 6361 tgtgtgagga gtccattgct gttggaaccg tgaagcacga ggggaatatc aaatacgtga 6421 acgacgtgag gaacatcaca aagaaaaata ttgaagaatg gggcccattt gacttggtga 6481 ttggcggaag cccatgcaac gatctctcaa atgtgaatcc agccaggaaa ggcctgtatg 6541 agggtacagg ccggctcttc ttcgaatttt accacctgct gaattactca cgccccaagg 6601 agggtgatga ccggccgttc ttctggatgt ttgagaatgt tgtagccatg aaggttggcg 6661 acaagaggga catctcacgg ttcctggagt gtaatccagt gatgattgat gccatcaaag 6721 tttctgctgc tcacagggcc cgatacttct ggggcaacct acccgggatg aacaggatct 6781 ttggctttcc tgtgcactac acagacgtgt ccaacatggg ccgtggtgcc cgccagaagc 6841 tgctgggaag gtcctggagc gtgcctgtca tccgacacct cttcgcccct ctgaaggact 6901 actttgcatg tgaatagGAC CCAGCTTTCT TGTACAAAGT GGTGATggcc GCTCTAGCTA 6961 GTCGATAAGC TAATTCCGCC CCCCCCCCCC CCCCCCCCTC ACCcTCCCCC CCCCctaacg 7021 ttactggccg aagccgcttg gaataaggcc ggtgagcgtt tgtctatatg ttattttcca 7081 ccatattgcc gtcttttggc aatgtgaggg cccgaaacct ggccctgtct tcttgacgac 7141 gattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa 7201 ggaagcagtt cctctggaag cttcttgaag acaacaacgt ctgtagcgac cctttgcagg 7261 cagcggaacc ccccacctgg cgacatggat agttgtggaa agagtcaaat ggctctcctc 7321 aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga 7381 tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa acgtctaggc 7441 cccccgaacc acggggacgt ggttttggtt tgaaaaacac gatgataata tggccacaac 7501 catggaacag ggggatcagc ttaccatggc caagatccct cctaagaaga agcgcaaagt 7561 cgaggatccc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa 7621 tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga 7681 tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg cgctttgcct ggtttccggc 7741 accagaagcg gtgccggaaa gctggctgga gtgcgatctt cctgaggccg atactgtcgt 7801 cgtcccctca aactggcaga tgcacggtta cgatgcgccc atctacacca acgtaaccta 7861 tcccattacg gtcaatccgc cgtttgttcc cacggagaat ccgacgggtt gttactcgct 7921 cacatttaat gttgatgaaa gctggctaca ggaaggccag acgcgaatta tttttgatgg 7981 cgttaactcg gcgtttcatc tgtggtgcaa cgggcgctgg gtcggttacg gccaggacag 8041 tcgtttgccg tctgaatttg acctgagcgc atttttacgc gccggagaaa accgcctcgc 8101 ggtgatggtg ctgcgttgga gtgacggcag ttatctggaa gatcaggata tgtggcggat 8161 gagcggcatt ttccgtgacg tctcgttgct gcataaaccg actacacaaa tcagcgattt 8221 ccatgttgcc actcgcttta atgatgattt cagccgcgct gtactggagg ctgaagttca 8281 gatgtgcggc gagttgcgtg actacctacg ggtaacagtt tctttatggc agggtgaaac 8341 gcaggtcgcc agcggcaccg cgcctttcgg cggtgaaatt atcgatgagc gtggtggtta 8401 tgccgatcgc gtcacactac gtctgaacgt cgaaaacccg aaactgtgga gcgccgaaat 8461 cccgaatctc tatcgtgcgg tggttgaact gcacaccgcc gacggcacgc tgattgaagc 8521 agaagcctgc gatgtcggtt tccgcgaggt gcggattgaa aatggtctgc tgctgctgaa 8581 cggcaagccg ttgctgattc gaggcgttaa ccgtcacgag catcatcctc tgcatggtca 8641 ggtcatggat gagcagacga tggtgcagga tatcctgctg atgaagcaga acaactttaa 8701 cgccgtgcgc tgttcgcatt atccgaacca tccgctgtgg tacacgctgt gcgaccgcta 8761 cggcctgtat gtggtggatg aagccaatat tgaaacccac ggcatggtgc caatgaatcg 8821 tctgaccgat gatccgcgct ggctaccggc gatgagcgaa cgcgtaacgc gaatggtgca 8881 gcgcgatcgt aatcacccga gtgtgatcat ctggtcgctg gggaatgaat caggccacgg 8941 cgctaatcac gacgcgctgt atcgctggat caaatctgtc gatccttccc gcccggtgca 9001 gtatgaaggc ggcggagccg acaccacggc caccgatatt atttgcccga tgtacgcgcg 9061 cgtggatgaa gaccagccct tcccggctgt gccgaaatgg tccatcaaaa aatggctttc 9121 gctacctgga gagacgcgcc cgctgatcct ttgcgaatac gcccacgcga tgggtaacag 9181 tcttggcggt ttcgctaaat actggcaggc gtttcgtcag tatccccgtt tacagggcgg 9241 cttcgtctgg gactgggtgg atcagtcgct gattaaatat gatgaaaacg gcaacccgtg 9301 gtcggcttac ggcggtgatt ttggcgatac gccgaacgat cgccagttct gtatgaacgg 9361 tctggtcttt gccgaccgca cgccgcatcc agcgctgacg gaagcaaaac accagcagca 9421 gtttttccag ttccgtttat ccgggcaaac catcgaagtg accagcgaat acctgttccg 9481 tcatagcgat aacgagctcc tgcactggat ggtggcgctg gatggtaagc cgctggcaag 9541 cggtgaagtg cctctggatg tcgctccaca aggtaaacag ttgattgaac tgcctgaact 9601 accgcagccg gagagcgccg ggcaactctg gctcacagta cgcgtagtgc aaccgaacgc 9661 gaccgcatgg tcagaagccg ggcacatcag cgcctggcag cagtggcgtc tggcggaaaa 9721 cctcagtgtg acgctccccg ccgcgtccca cgccatcccg catctgacca ccagcgaaat 9781 ggatttttgc atcgagctgg gtaataagcg ttggcaattt aaccgccagt caggctttct 9841 ttcacagatg tggattggcg ataaaaaaca actgctgacg ccgctgcgcg atcagttcac 9901 ccgtgcaccg ctggataacg acattggcgt aagtgaagcg acccgcattg accctaacgc 9961 ctgggtcgaa cgctggaagg cggcgggcca ttaccaggcc gaagcagcgt tgttgcagtg 10021 cacggcagat acacttgctg atgcggtgct gattacgacc gctcacgcgt ggcagcatca 10081 ggggaaaacc ttatttatca gccggaaaac ctaccggatt gatggtagtg gtcaaatggc 10141 gattaccgtt gatgttgaag tggcgagcga tacaccgcat ccggcgcgga ttggcctgaa 10201 ctgccagctg gcgcaggtag cagagcgggt aaactggctc ggattagggc cgcaagaaaa 10261 ctatcccgac cgccttactg ccgcctgttt tgaccgctgg gatctgccat tgtcagacat 10321 gtataccccg tacgtcttcc cgagcgaaaa cggtctgcgc tgcgggacgc gcgaattgaa 10381 ttatggccca caccagtggc gcggcgactt ccagttcaac atcagccgct acagtcaaca 10441 gcaactgatg gaaaccagcc atcgccatct gctgcacgcg gaagaaggca catggctgaa 10501 tatcgacggt ttccatatgg ggattggtgg cgacgactcc tggagcccgt cagtatcggc 10561 ggaattccag ctgagcgccg gtcgctacca ttaccagttg gtctggtgtc aggggatccc 10621 ccgggctgca gccaatatgg gatcggccat tgaacaagat ggattgcacg caggttctcc 10681 ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc 10741 tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga 10801 cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt ggctggccac 10861 gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct 10921 gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa 10981 agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc 11041 attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct 11101 tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc 11161 caggctcaag gcgcgcatgc ccgacggcga tgatctcgtc gtgacccatg gcgatgcctg 11221 cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct 11281 gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct 11341 tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca 11401 gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga ggggatcaat tctctagggc 11461 tcgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc 11521 cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga 11581 aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga 11641 cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat 11701 ggcttctgag gcggaaagaa ccagctgggg ctcgatcctc tagagtcgaG GGCTGCAGGA 11761 ATTCGATATC AAGCTCTAGC CAACAAGCTC GTCATCGCTT TGCAGAAGAG CAGAGAGGAT 11821 ATGCTCATCG TCTAAAGAAC TACCCATTTT ATTATATATT AGTCACgata tctataacaa 11881 gaaaatatat atataataag ttatcacgta agtagaacat gaaataacaa tataattatc 11941 gtatgagtta aatcttaaaa gtcacgtaaa agataatcat gcgtcatttt gactcacgcg 12001 gtcgttatag ttcaaaatca gtgacactta ccgcattgac aagcacgcct cacgggagct 12061 ccaagcggcg actgagatgt cctaaatgca cagcgacgga ttcgcgctat ttagaaagag 12121 agagcaatat ttcaagaATG CATgcgtcaa ttttacgcag actatctttc tagggttaaA 12181 tttAAAtGAT TTGCGCTTTA CTCGACCTAA ACTTTAAACA CGTCATAGAA TCTTCGTTTG 12241 ACAAAAACCA CATTGTGGCC AAGCTGTGTG ACGCGACGCG CGCTAAAGAA TGGCAAACCA 12301 AGTCGCGCGA GGTACCCAGC TTTTGTTCCC TTTAGTGAGG GTTAATTCCG AGCTTGGCGT 12361 AATCATGGTC ATAGCTGTTT CCTGTGTGAA ATTGTTATCC GCTCACAATT CCACACAACA 12421 TACGAGCCGG AAGCATAAAG TGTAAAGCCT GGGGTGCCTA ATGAGTGAGC TAACTCACAT 12481 TAATTGCGTT GCGCTCACTG CCCGCTTTCC AGTCGGGAAA CCTGTCGTGC CAGCTGCATT 12541 AATGAATCGG CCAACGCGCG GGGAGAGGCG GTTTGCGTAT TGGGCGCTCT TCCGCTTCCT 12601 CGCTCACTGA CTCGCTGCGC TCGGTCGTTC GGCTGCGGCG AGCGGTATCA GCTCACTCAA 12661 AGGCGGTAAT ACGGTTATCC ACAGAATCAG GGGATAACGC AGGAAAGAAC ATGTGAGCAA 12721 AAGGCCAGCA AAAGGCCAGG AACCGTAAAA AGGCCGCGTT GCTGGCGTTT TTCCATAGGC 12781 TCCGCCCCCC TGACGAGCAT CACAAAAATC GACGCTCAAG TCAGAGGTGG CGAAACCCGA 12841 CAGGACTATA AAGATACCAG GCGTTTCCCC CTGGAAGCTC CCTCGTGCGC TCTCCTGTTC 12901 CGACCCTGCC GCTTACCGGA TACCTGTCCG CCTTTCTCCC TTCGGGAAGC GTGGCGCTTT 12961 CTCATAGCTC ACGCTGTAGG TATCTCAGTT CGGTGTAGGT CGTTCGCTCC AAGCTGGGCT 13021 GTGTGCACGA ACCCCCCGTT CAGCCCGACC GCTGCGCCTT ATCCGGTAAC TATCGTCTTG 13081 AGTCCAACCC GGTAAGACAC GACTTATCGC CACTGGCAGC AGCCACTGGT AACAGGATTA 13141 GCAGAGCGAG GTATGTAGGC GGTGCTACAG AGTTCTTGAA GTGGTGGCCT AACTACGGCT 13201 ACACTAGAAG GACAGTATTT GGTATCTGCG CTCTGCTGAA GCCAGTTACC TTCGGAAAAA 13261 GAGTTGGTAG CTCTTGATCC GGCAAACAAA CCACCGCTGG TAGCGGTGGT TTTTTTGTTT 13321 GCAAGCAGCA GATTACGCGC AGAAAAAAAG GATCTCAAGA AGATCCTTTG ATCTTTTCTA 13381 CGGGGTCTGA CGCTCAGTGG AACGAAAACT CACGTTAAGG GATTTTGGTC ATGAGATTAT 13441 CAAAAAGGAT CTTCACCTAG ATCCTTTTAA ATTAAAAATG AAGTTTTAAA TCAATCTAAA 13501 GTATATATGA GTAAACTTGG TCTGACAGTT ACCAATGCTT AATCAGTGAG GCACCTATCT 13561 CAGCGATCTG TCTATTTCGT TCATCCATAG TTGCCTGACT CCCCGTCGTG TAGATAACTA 13621 CGATACGGGA GGGCTTACCA TCTGGCCCCA GTGCTGCAAT GATACCGCGA GACCCACGCT 13681 CACCGGCTCC AGATTTATCA GCAATAAACC AGCCAGCCGG AAGGGCCGAG CGCAGAAGTG 13741 GTCCTGCAAC TTTATCCGCC TCCATCCAGT CTATTAATTG TTGCCGGGAA GCTAGAGTAA 13801 GTAGTTCGCC AGTTAATAGT TTGCGCAACG TTGTTGCCAT TGCTACAGGC ATCGTGGTGT 13861 CACGCTCGTC GTTTGGTATG GCTTCATTCA GCTCCGGTTC CCAACGATCA AGGCGAGTTA 13921 CATGATCCCC CATGTTGTGC AAAAAAGCGG TTAGCTCCTT CGGTCCTCCG ATCGTTGTCA 13981 GAAGTAAGTT GGCCGCAGTG TTATCACTCA TGGTTATGGC AGCACTGCAT AATTCTCTTA 14041 CTGTCATGCC ATCCGTAAGA TGCTTTTCTG TGACTGGTGA GTACTCAACC AAGTCATTCT 14101 GAGAATAGTG TATGCGGCGA CCGAGTTGCT CTTGCCCGGC GTCAATACGG GATAATACCG 14161 CGCCACATAG CAGAACTTTA AAAGTGCTCA TCATTGGAAA ACGTTCTTCG GGGCGAAAAC 14221 TCTCAAGGAT CTTACCGCTG TTGAGATCCA GTTCGATGTA ACCCACTCGT GCACCCAACT 14281 GATCTTCAGC ATCTTTTACT TTCACCAGCG TTTCTGGGTG AGCAAAAACA GGAAGGCAAA 14341 ATGCCGCAAA AAAGGGAATA AGGGCGACAC GGAAATGTTG AATACTCATA CTCTTCCTTT 14401 TTCAATATTA TTGAAGCATT TATCAGGGTT ATTGTCTCAT GAGCGGATAC ATATTTGAAT 14461 GTATTTAGAA AAATAAACAA ATAGGGGTTC CGCGCACATT TCCCCGAAAA GTGCCACCTG //