LOCUS 91393_PB_tet_PHs 13459 bp ds-DNA circular 29-JUL-2013 DEFINITION . ACCESSION VERSION SOURCE . ORGANISM . COMMENT Insert from 91152 pORF-DNMT3L 652 to 1948 COMMENT Backbone from 90946 PB-tet-PH-lox66FRT2 6253 to 4570 COMMENT ApEinfo:methylated:1 FEATURES Location/Qualifiers source 4644..5801 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:1090 IMAGE:3138514" /tissue_type="Placenta, choriocarcinoma" /clone_lib="NIH_MGC_21" /lab_host="DH10B-R" /note="Vector: pOTB7" /label=Vector: pOTB7 /ApEinfo_fwdcolor=#ffffff /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1205..1459 /label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 707..941 /label=PB 3'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 gene 4644..5801 /gene="DNMT3L" /gene_synonym="MGC1090" /db_xref="GeneID:29947" /db_xref="HGNC:2980" /db_xref="MIM:606588" /label=DNMT3L /ApEinfo_fwdcolor=#ff0080 /ApEinfo_revcolor=#004080 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3331..3678 /label=polyA /ApEinfo_fwdcolor=#ff8080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 4644..5801 /gene="DNMT3L" /gene_synonym="MGC1090" /codon_start=1 /product="DNA (cytosine-5-)-methyltransferase 3-like" /protein_id="AAH02560.1" /db_xref="GI:12803471" /db_xref="GeneID:29947" /db_xref="HGNC:2980" /db_xref="MIM:606588" /translation="MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKA NQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSG ETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKW RSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQL KHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGS PGPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRH WALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL" /label=DNA (cytosine-5-)-methyltransferase 3-like /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4446..4551 /label=mCMV promoter /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_difference 5475..5475 /gene="DNMT3L" /gene_synonym="MGC1090" /note="'G' in cDNA is 'A' in the human genome; amino acid difference: 'G' in cDNA, 'R' in the human genome. The chimpanzee genome agrees with the human genomic sequence and not the cDNA." /label=DNMT3L(1) /ApEinfo_label=DNMT3L /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1460..1711 /label=mouse PGK promoter(1) /ApEinfo_label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4571..4587 /label=attL1 /ApEinfo_fwdcolor=#ff0000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 6591..6659 /label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4160..4437 /label=8xTetO2 element /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5858..5867 /label=attL2 /ApEinfo_fwdcolor=#ff0000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 618..645 /label=T7 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4644..5801 /label=DNMT3L(2) /ApEinfo_label=DNMT3L /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5914..6437 /label=IRES /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3685..3926 /label=chicken 5'-HS4 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5293..5801 /label=sequenced /ApEinfo_fwdcolor=#004080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4644..5142 /label=sequenced(1) /ApEinfo_label=sequenced /ApEinfo_fwdcolor=#004080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 602..619 /label=M13-fwd /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature complement(5868..5882) /label=AttR2 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1732..2328 /label=Pac /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6439..10381 /label=b-geo /ApEinfo_fwdcolor=#800000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6502..9527 /label=LacZ /ApEinfo_fwdcolor=#00ffff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10382..10688 /label=pA /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10806..11076 /label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(135..441) /label=F1 ori /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(11266..11285) /label=T3 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(3..458) /label=M13 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(11303..11323) /label=M13-rev /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 2335..3330 /label=DeltaTK /ApEinfo_fwdcolor=#0000ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(11691..12373) /label=ColE1 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_binding complement(11329..11351) /label=LacO /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4563..4570 /label=AttR1 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(12471..13130) /label=AmpR /ApEinfo_fwdcolor=yellow /ApEinfo_revcolor=yellow /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 11077..11118 /label=PB 5'LTR(1) /ApEinfo_label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(463..531) /label=LacZ alpha(1) /ApEinfo_label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 ORIGIN 1 GGAAATTGTA AACGTTAATA TTTTGTTAAA ATTCGCGTTA AATTTTTGTT AAATCAGCTC 61 ATTTTTTAAC CAATAGGCCG AAATCGGCAA AATCCCTTAT AAATCAAAAG AATAGACCGA 121 GATAGGGTTG AGTGTTGTTC CAGTTTGGAA CAAGAGTCCA CTATTAAAGA ACGTGGACTC 181 CAACGTCAAA GGGCGAAAAA CCGTCTATCA GGGCGATGGC CCACTACGTG AACCATCACC 241 CTAATCAAGT TTTTTGGGGT CGAGGTGCCG TAAAGCACTA AATCGGAACC CTAAAGGGAG 301 CCCCCGATTT AGAGCTTGAC GGGGAAAGCC GGCGAACGTG GCGAGAAAGG AAGGGAAGAA 361 AGCGAAAGGA GCGGGCGCTA GGGCGCTGGC AAGTGTAGCG GTCACGCTGC GCGTAACCAC 421 CACACCCGCC GCGCTTAATG CGCCGCTACA GGGCGCGTCG CGCCATTCGC CATTCAGGCT 481 GCGCAACTGT TGGGAAGGGC GATCGGTGCG GGCCTCTTCG CTATTACGCC AGCTGGCGAA 541 AGGGGGATGT GCTGCAAGGC GATTAAGTTG GGTAACGCCA GGGTTTTCCC AGTCACGACG 601 TTGTAAAACG ACGGCCAGTG AATTGTAATA CGACTCACTA TAGGGCGAAT TGGAGCTCGG 661 TATTCACGAC AGCAGGCTGA ATAATAAAAA AATTAGAAAC TATTATttaa ccctagaaag 721 ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc atgtgtttta 781 tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt tattatattt 841 acacttacat actaataata aattcaacaa acaatttatt tatgtttatt tatttattaa 901 aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttaAA CATTCTCTCT 961 TTTACAAAAA TAAACTTATT TTGTACTTTA AAAACAGTCA TGTTGTATTA TAAAATAAGT 1021 AATTAGCTTA ACCTATACAT AATAGAAACA AATTATACTT ATTAGTCAGT CAGAAACAAC 1081 TTTGGCACAT ATCAATATTA TGCTCTCGTT ACTGGCGAAA GGGGGATGTG CTGCAAGGCG 1141 ATTAAGTTGG GTAACGCCAG GGTTTTCCCA GTCACGACGT TGTAAAACGA CGGCCAGTGA 1201 ATTCtaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc 1261 cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac 1321 cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc 1381 cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga 1441 agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt 1501 aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct 1561 gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg 1621 aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt 1681 ctcctcttcc tcatctccgg gcctttcgac cGATCATCAA GCTTGATCCT Catgaccgag 1741 tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccAgggccgt acgcaccctc 1801 gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgaTccgga ccgccacatc 1861 gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag 1921 gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa 1981 gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg 2041 gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg 2101 ttcctggcca ccgtcggcgt ctcgcccgac caccagggca agggtctggg cagcgccgtc 2161 gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacctcc 2221 gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag 2281 Gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgccgg atccATGCCC 2341 ACGCTACTGC GGGTTTATAT AGACGGTCCC CACGGGATGG GGAAAACCAC CACCACGCAA 2401 CTGCTGGTGG CCCTGGGTTC GCGCGACGAT ATCGTCTACG TACCCGAGCC GATGACTTAC 2461 TGGCGGGTGc TGGGGGCTTC CGAGACAATC GCGAACATCT ACACCACACA ACACCGCCTC 2521 GACCAGGGTG AGATATCGGC CGGGGACGCG GCGGTGGTAA TGACAAGCGC CCAGATAACA 2581 ATGGGCATGC CTTATGCCGT GACCGACGCC GTTCTGGCTC CTCATATCGG GGGGGAGGCT 2641 GGGAGCTCAC ATGCCCCGCC CCCGGCCCTC ACCCTCATCT TCGACCGCCA TCCCATCGCC 2701 GCCCTCCTGT GCTACCCGGC CGCGCGgTAC CTTATGGGCA GCATGACCCC CCAGGCCGTG 2761 CTGGCGTTCG TGGCCCTCAT CCCGCCGACC TTGCCCGGCA CcAACATCGT GcTTGGGGCC 2821 CTTCCGGAGG ACAGACACAT CGACCGCCTG GCCAAACGCC AGCGCCCCGG CGAGCGGCTg 2881 GACCTGGCTA TGCTGGCtGC GATTCGCCGC GTTTAcGGGC TaCTTGCCAA TACGGTGCGG 2941 TATCTGCAGt GCGGCGGGTC GTGGCGGGAG GAcTGGGGAC AGCTTTCGGG GaCGGCCGTG 3001 CCGCCCCAGG GTGCCGAGCC CCAGAGCAAC GCGGGCCCAC GACCCCATAT CGGGGACACG 3061 TTATTTACCC TGTTTCGGGC CCCCGAGTTG CTGGCCCCCA ACGGCGACCT GTATAACGTG 3121 TTTGCCTGGG CcTTGGACGT CTTGGCCAAA CGCCTCCGTT CCATGCACGT CTTTATCCTG 3181 GATTACGACC AATCGCCCGC CGGCTGCCGG GACGCCCTGC TGCAACTTAC CTCCGGGATG 3241 GTCCAGACCC ACGTCACCAC CCCCGGCTCC ATACCGACGA TATGCGACCT GGCGCGCACG 3301 TTTGCCCGGG AGATGGGGGA GGCTAACTGA gctctagctt atcgactcgc cgatagtgga 3361 aaccgacgcc ccagcactcg tccgagggca aaggaatagt cgagaaattg atgatctatt 3421 aaacaataaa gatgtccaca tggaagtttt tcctgtcata ctttgttaag aagggtgaga 3481 acagagtacc tacattttga atggaaggat tggagctacg ggggtggggg tggggtggga 3541 ttagataaat gcctgctctt tactgaaggc tctttactat tgctttatga taatgtttca 3601 tagttggata tcataattta aacaagcaaa accaaattaa gggccagctc attcctccca 3661 ctcatgatct atagatccTc tagaGAGCTC ACGGGGACAG CCCCCCCCCA AAGCCCCCAG 3721 GGATGTAATT ACGTCCCTCC CCCGCTAGGG GGCAGCAGCG AGCCGCCCGG GGCTCCGCTC 3781 CGGTCCGGCG CTCCCCCCGC ATCCCCGAGC CGGCAGCGTG CGGGGACAGC CCGGGCACGG 3841 GGAAGGTGGC ACGGGATCGC TTTCCTCTGA ACGCTTCTCG CTGCTCTTTG AGCCTGCAGA 3901 CACCTGGGGG ATACGGGGAA AAAGCTgtcg aCCTGCAGGC ATGCAAGCTT GGCGTAATCA 3961 TGGTCATAGC TGTTTCCTGT GTGAAATTGT TATCCGCTCA CAATTCCACA CAACATACGA 4021 GCCGGAAGCA TAAAGTGTAA AGCCTGGGGT GCCTAATGAG TGAGCTAACT CACATTAATT 4081 GCGTTGCGCT CACTGCCCGC TTTCCAGTCG GGAAACCTGT CGTGCCAGTA ACTCGAGGGA 4141 TCCAAGCTgg CCgcACGTCT CCCTATCAGT GATAGAGAAG TCGACACGTC TCGAGCTCCC 4201 TATCAGTGAT AGAGAAGGTA CGTCTAGAAC GTCTCCCTAT CAGTGATAGA GAAGTCGACA 4261 CGTCTCGAGC TCCCTATCAG TGATAGAGAA GGTACGTCTA GAACGTCTCC CTATCAGTGA 4321 TAGAGAAGTC GACACGTCTC GAGCTCCCTA TCAGTGATAG AGAAGGTACG TCTAGAACGT 4381 CTCCCTATCA GTGATAGAGA AGTCGACACG TCTCGAGCTC CCTATCAGTG ATAGAGAAGG 4441 TACCCCCTAT ATAAGCAGAG CTCGTTTAGT GAACCGTCAG ATCGCCTGGA GACGCCATCC 4501 ACGCTGTTTT GACCTCCATA GAAGACACCG GGACCGATCC AGCCTCCGCG GTGGCGGCCA 4561 TCACAAGTTT GTACAAAAAA GCAGGCTCCG CGGCCGCCCC CTTCACCGCT AGGGATAACA 4621 GGGTAATAGA AGGAGCCGCC ACCatggcgg ccatcccagc cctggaccca gaggccgagc 4681 ccagcatgga cgtgattttg gtgggatcca gtgagctctc aagctccgtt tcacccggga 4741 caggcagaga tcttattgca tatgaagtca aggctaacca gcgaaatata gaagacatct 4801 gcatctgctg cggaagtctc caggttcaca cacagcaccc tctgtttgag ggagggatct 4861 gcgccccatg taaggacaag ttcctggatg ccctcttcct gtacgacgat gacgggtacc 4921 aatcctactg ctccatctgc tgctccggag agacgctgct catctgcgga aaccctgatt 4981 gcacccgatg ctactgcttc gagtgtgtgg atagcctggt cggccccggg acctcgggga 5041 aggtgcacgc catgagcaac tgggtgtgct acctgtgcct gccgtcctcc cgaagcgggc 5101 tgctgcagcg tcggaggaag tggcgcagcc agctcaaggc cttctacgac cgagagtcgg 5161 agaatcccct tgagatgttc gaaaccgtgc ctgtgtggag gagacagcca gtccgggtgc 5221 tgtccctttt tgaagacatc aagaaagagc tgacgagttt gggctttttg gaaagtggtt 5281 ctgacccggg acaactgaag catgtggttg atgtcacaga cacagtgagg aaggatgtgg 5341 aggagtgggg acccttcgat cttgtgtacg gcgccacacc tcccctgggc cacacctgtg 5401 accgtcctcc cagctggtac ctgttccagt tccaccggct cctgcagtac gcacggccca 5461 agccaggcag ccccgggccc ttcttctgga tgttcgtgga caatctggtg ctgaacaagg 5521 aagacctgga cgtcgcatct cgcttcctgg agatggagcc agtcaccatc ccagatgtcc 5581 acggcggatc cttgcagaat gctgtccgcg tgtggagcaa catcccagcc ataaggagca 5641 ggcactgggc tctggtttcg gaagaagaat tgtccctgct ggcccagaac aagcagagct 5701 cgaagctcgc ggccaagtgg cccaccaagc tggtgaagaa ctgctttctc cccctaagag 5761 aatatttcaa gtatttttca acagaactca cttcctcttt aTGAGTTTCC TGTGAACAAT 5821 TGCTCCTCTC TTAAGGTAGC AAAGGGTGGG CGCGCCGACC CAGCTTTCTT GTACAAAGTG 5881 GTGATggccG CTCTAGCTAG TCGATAAGCT AATTCCGCCC CCCCCCCCCC CCCCCCCTCA 5941 CCcTCCCCCC CCCctaacgt tactggccga agccgcttgg aataaggccg gtgagcgttt 6001 gtctatatgt tattttccac catattgccg tcttttggca atgtgagggc ccgaaacctg 6061 gccctgtctt cttgacgacg attcctaggg gtctttcccc tctcgccaaa ggaatgcaag 6121 gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caacaacgtc 6181 tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacatggata gttgtggaaa 6241 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 6301 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 6361 ggttaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttggttt gaaaaacacg 6421 atgataatat ggccacaacc atggaacagg gggatcagct taccatggcc aagatccctc 6481 ctaagaagaa gcgcaaagtc gaggatcccg tcgttttaca acgtcgtgac tgggaaaacc 6541 ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata 6601 gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc 6661 gctttgcctg gtttccggca ccagaagcgg tgccggaaag ctggctggag tgcgatcttc 6721 ctgaggccga tactgtcgtc gtcccctcaa actggcagat gcacggttac gatgcgccca 6781 tctacaccaa cgtaacctat cccattacgg tcaatccgcc gtttgttccc acggagaatc 6841 cgacgggttg ttactcgctc acatttaatg ttgatgaaag ctggctacag gaaggccaga 6901 cgcgaattat ttttgatggc gttaactcgg cgtttcatct gtggtgcaac gggcgctggg 6961 tcggttacgg ccaggacagt cgtttgccgt ctgaatttga cctgagcgca tttttacgcg 7021 ccggagaaaa ccgcctcgcg gtgatggtgc tgcgttggag tgacggcagt tatctggaag 7081 atcaggatat gtggcggatg agcggcattt tccgtgacgt ctcgttgctg cataaaccga 7141 ctacacaaat cagcgatttc catgttgcca ctcgctttaa tgatgatttc agccgcgctg 7201 tactggaggc tgaagttcag atgtgcggcg agttgcgtga ctacctacgg gtaacagttt 7261 ctttatggca gggtgaaacg caggtcgcca gcggcaccgc gcctttcggc ggtgaaatta 7321 tcgatgagcg tggtggttat gccgatcgcg tcacactacg tctgaacgtc gaaaacccga 7381 aactgtggag cgccgaaatc ccgaatctct atcgtgcggt ggttgaactg cacaccgccg 7441 acggcacgct gattgaagca gaagcctgcg atgtcggttt ccgcgaggtg cggattgaaa 7501 atggtctgct gctgctgaac ggcaagccgt tgctgattcg aggcgttaac cgtcacgagc 7561 atcatcctct gcatggtcag gtcatggatg agcagacgat ggtgcaggat atcctgctga 7621 tgaagcagaa caactttaac gccgtgcgct gttcgcatta tccgaaccat ccgctgtggt 7681 acacgctgtg cgaccgctac ggcctgtatg tggtggatga agccaatatt gaaacccacg 7741 gcatggtgcc aatgaatcgt ctgaccgatg atccgcgctg gctaccggcg atgagcgaac 7801 gcgtaacgcg aatggtgcag cgcgatcgta atcacccgag tgtgatcatc tggtcgctgg 7861 ggaatgaatc aggccacggc gctaatcacg acgcgctgta tcgctggatc aaatctgtcg 7921 atccttcccg cccggtgcag tatgaaggcg gcggagccga caccacggcc accgatatta 7981 tttgcccgat gtacgcgcgc gtggatgaag accagccctt cccggctgtg ccgaaatggt 8041 ccatcaaaaa atggctttcg ctacctggag agacgcgccc gctgatcctt tgcgaatacg 8101 cccacgcgat gggtaacagt cttggcggtt tcgctaaata ctggcaggcg tttcgtcagt 8161 atccccgttt acagggcggc ttcgtctggg actgggtgga tcagtcgctg attaaatatg 8221 atgaaaacgg caacccgtgg tcggcttacg gcggtgattt tggcgatacg ccgaacgatc 8281 gccagttctg tatgaacggt ctggtctttg ccgaccgcac gccgcatcca gcgctgacgg 8341 aagcaaaaca ccagcagcag tttttccagt tccgtttatc cgggcaaacc atcgaagtga 8401 ccagcgaata cctgttccgt catagcgata acgagctcct gcactggatg gtggcgctgg 8461 atggtaagcc gctggcaagc ggtgaagtgc ctctggatgt cgctccacaa ggtaaacagt 8521 tgattgaact gcctgaacta ccgcagccgg agagcgccgg gcaactctgg ctcacagtac 8581 gcgtagtgca accgaacgcg accgcatggt cagaagccgg gcacatcagc gcctggcagc 8641 agtggcgtct ggcggaaaac ctcagtgtga cgctccccgc cgcgtcccac gccatcccgc 8701 atctgaccac cagcgaaatg gatttttgca tcgagctggg taataagcgt tggcaattta 8761 accgccagtc aggctttctt tcacagatgt ggattggcga taaaaaacaa ctgctgacgc 8821 cgctgcgcga tcagttcacc cgtgcaccgc tggataacga cattggcgta agtgaagcga 8881 cccgcattga ccctaacgcc tgggtcgaac gctggaaggc ggcgggccat taccaggccg 8941 aagcagcgtt gttgcagtgc acggcagata cacttgctga tgcggtgctg attacgaccg 9001 ctcacgcgtg gcagcatcag gggaaaacct tatttatcag ccggaaaacc taccggattg 9061 atggtagtgg tcaaatggcg attaccgttg atgttgaagt ggcgagcgat acaccgcatc 9121 cggcgcggat tggcctgaac tgccagctgg cgcaggtagc agagcgggta aactggctcg 9181 gattagggcc gcaagaaaac tatcccgacc gccttactgc cgcctgtttt gaccgctggg 9241 atctgccatt gtcagacatg tataccccgt acgtcttccc gagcgaaaac ggtctgcgct 9301 gcgggacgcg cgaattgaat tatggcccac accagtggcg cggcgacttc cagttcaaca 9361 tcagccgcta cagtcaacag caactgatgg aaaccagcca tcgccatctg ctgcacgcgg 9421 aagaaggcac atggctgaat atcgacggtt tccatatggg gattggtggc gacgactcct 9481 ggagcccgtc agtatcggcg gaattccagc tgagcgccgg tcgctaccat taccagttgg 9541 tctggtgtca ggggatcccc cgggctgcag ccaatatggg atcggccatt gaacaagatg 9601 gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat gactgggcac 9661 aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag gggcgcccgg 9721 ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac gaggcagcgc 9781 ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg 9841 aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc ctgtcatctc 9901 accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg ctgcatacgc 9961 ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta 10021 ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat caggggctcg 10081 cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgat gatctcgtcg 10141 tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc ttttctggat 10201 tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg ttggctaccc 10261 gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta 10321 tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgag 10381 gggatcaatt ctctagggct cgctgatcag cctcgactgt gccttctagt tgccagccat 10441 ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc 10501 tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg 10561 ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg 10621 gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc tcgatcctct 10681 agagtcgaGG GCTGCAGGAA TTCGATATCA AGCTCTAGCC AACAAGCTCG TCATCGCTTT 10741 GCAGAAGAGC AGAGAGGATA TGCTCATCGT CTAAAGAACT ACCCATTTTA TTATATATTA 10801 GTCACgatat ctataacaag aaaatatata tataataagt tatcacgtaa gtagaacatg 10861 aaataacaat ataattatcg tatgagttaa atcttaaaag tcacgtaaaa gataatcatg 10921 cgtcattttg actcacgcgg tcgttatagt tcaaaatcag tgacacttac cgcattgaca 10981 agcacgcctc acgggagctc caagcggcga ctgagatgtc ctaaatgcac agcgacggat 11041 tcgcgctatt tagaaagaga gagcaatatt tcaagaATGC ATgcgtcaat tttacgcaga 11101 ctatctttct agggttaaAt ttAAAtGATT TGCGCTTTAC TCGACCTAAA CTTTAAACAC 11161 GTCATAGAAT CTTCGTTTGA CAAAAACCAC ATTGTGGCCA AGCTGTGTGA CGCGACGCGC 11221 GCTAAAGAAT GGCAAACCAA GTCGCGCGAG GTACCCAGCT TTTGTTCCCT TTAGTGAGGG 11281 TTAATTCCGA GCTTGGCGTA ATCATGGTCA TAGCTGTTTC CTGTGTGAAA TTGTTATCCG 11341 CTCACAATTC CACACAACAT ACGAGCCGGA AGCATAAAGT GTAAAGCCTG GGGTGCCTAA 11401 TGAGTGAGCT AACTCACATT AATTGCGTTG CGCTCACTGC CCGCTTTCCA GTCGGGAAAC 11461 CTGTCGTGCC AGCTGCATTA ATGAATCGGC CAACGCGCGG GGAGAGGCGG TTTGCGTATT 11521 GGGCGCTCTT CCGCTTCCTC GCTCACTGAC TCGCTGCGCT CGGTCGTTCG GCTGCGGCGA 11581 GCGGTATCAG CTCACTCAAA GGCGGTAATA CGGTTATCCA CAGAATCAGG GGATAACGCA 11641 GGAAAGAACA TGTGAGCAAA AGGCCAGCAA AAGGCCAGGA ACCGTAAAAA GGCCGCGTTG 11701 CTGGCGTTTT TCCATAGGCT CCGCCCCCCT GACGAGCATC ACAAAAATCG ACGCTCAAGT 11761 CAGAGGTGGC GAAACCCGAC AGGACTATAA AGATACCAGG CGTTTCCCCC TGGAAGCTCC 11821 CTCGTGCGCT CTCCTGTTCC GACCCTGCCG CTTACCGGAT ACCTGTCCGC CTTTCTCCCT 11881 TCGGGAAGCG TGGCGCTTTC TCATAGCTCA CGCTGTAGGT ATCTCAGTTC GGTGTAGGTC 11941 GTTCGCTCCA AGCTGGGCTG TGTGCACGAA CCCCCCGTTC AGCCCGACCG CTGCGCCTTA 12001 TCCGGTAACT ATCGTCTTGA GTCCAACCCG GTAAGACACG ACTTATCGCC ACTGGCAGCA 12061 GCCACTGGTA ACAGGATTAG CAGAGCGAGG TATGTAGGCG GTGCTACAGA GTTCTTGAAG 12121 TGGTGGCCTA ACTACGGCTA CACTAGAAGG ACAGTATTTG GTATCTGCGC TCTGCTGAAG 12181 CCAGTTACCT TCGGAAAAAG AGTTGGTAGC TCTTGATCCG GCAAACAAAC CACCGCTGGT 12241 AGCGGTGGTT TTTTTGTTTG CAAGCAGCAG ATTACGCGCA GAAAAAAAGG ATCTCAAGAA 12301 GATCCTTTGA TCTTTTCTAC GGGGTCTGAC GCTCAGTGGA ACGAAAACTC ACGTTAAGGG 12361 ATTTTGGTCA TGAGATTATC AAAAAGGATC TTCACCTAGA TCCTTTTAAA TTAAAAATGA 12421 AGTTTTAAAT CAATCTAAAG TATATATGAG TAAACTTGGT CTGACAGTTA CCAATGCTTA 12481 ATCAGTGAGG CACCTATCTC AGCGATCTGT CTATTTCGTT CATCCATAGT TGCCTGACTC 12541 CCCGTCGTGT AGATAACTAC GATACGGGAG GGCTTACCAT CTGGCCCCAG TGCTGCAATG 12601 ATACCGCGAG ACCCACGCTC ACCGGCTCCA GATTTATCAG CAATAAACCA GCCAGCCGGA 12661 AGGGCCGAGC GCAGAAGTGG TCCTGCAACT TTATCCGCCT CCATCCAGTC TATTAATTGT 12721 TGCCGGGAAG CTAGAGTAAG TAGTTCGCCA GTTAATAGTT TGCGCAACGT TGTTGCCATT 12781 GCTACAGGCA TCGTGGTGTC ACGCTCGTCG TTTGGTATGG CTTCATTCAG CTCCGGTTCC 12841 CAACGATCAA GGCGAGTTAC ATGATCCCCC ATGTTGTGCA AAAAAGCGGT TAGCTCCTTC 12901 GGTCCTCCGA TCGTTGTCAG AAGTAAGTTG GCCGCAGTGT TATCACTCAT GGTTATGGCA 12961 GCACTGCATA ATTCTCTTAC TGTCATGCCA TCCGTAAGAT GCTTTTCTGT GACTGGTGAG 13021 TACTCAACCA AGTCATTCTG AGAATAGTGT ATGCGGCGAC CGAGTTGCTC TTGCCCGGCG 13081 TCAATACGGG ATAATACCGC GCCACATAGC AGAACTTTAA AAGTGCTCAT CATTGGAAAA 13141 CGTTCTTCGG GGCGAAAACT CTCAAGGATC TTACCGCTGT TGAGATCCAG TTCGATGTAA 13201 CCCACTCGTG CACCCAACTG ATCTTCAGCA TCTTTTACTT TCACCAGCGT TTCTGGGTGA 13261 GCAAAAACAG GAAGGCAAAA TGCCGCAAAA AAGGGAATAA GGGCGACACG GAAATGTTGA 13321 ATACTCATAC TCTTCCTTTT TCAATATTAT TGAAGCATTT ATCAGGGTTA TTGTCTCATG 13381 AGCGGATACA TATTTGAATG TATTTAGAAA AATAAACAAA TAGGGGTTCC GCGCACATTT 13441 CCCCGAAAAG TGCCACCTG //