LOCUS 91330_PB_tet_PHS 13432 bp ds-DNA circular 25-JUL-2013 DEFINITION . ACCESSION VERSION SOURCE . ORGANISM . COMMENT Insert from 91069 pORF-HDAC8(W01A062O18) 652 to 1921 COMMENT Backbone from 90946 PB-tet-PH-lox66FRT2 6253 to 4570 COMMENT ApEinfo:methylated:1 FEATURES Location/Qualifiers source 4644..5774 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:54166 IMAGE:5761745" /tissue_type="Lung, Spleen, fetal, pooled" /clone_lib="NIH_MGC_122" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" /label=Vector: pCMV-SPORT6 /ApEinfo_fwdcolor=#ffffff /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1205..1459 /label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 4644..5774 /gene="HDAC8" /gene_synonym="RPD3" /codon_start=1 /product="histone deacetylase 8" /protein_id="AAH50433.1" /db_xref="GI:30046561" /db_xref="GeneID:55869" /db_xref="HGNC:13315" /db_xref="MIM:300269" /translation="MEEPEEPADSGQSLVPVYIYSPEYVSMCDSPAKIPKRASMVHSL IEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDC PATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVL GILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVG LGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCS FNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDH EFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV" /label=histone deacetylase 8 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3331..3678 /label=polyA /ApEinfo_fwdcolor=#ff8080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_difference 4802..4802 /gene="HDAC8" /gene_synonym="RPD3" /note="'A' in cDNA is 'G' in the human genome; no amino acid change." /label=HDAC8 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 618..645 /label=T7 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4571..4587 /label=attL1 /ApEinfo_fwdcolor=#ff0000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1460..1711 /label=mouse PGK promoter(1) /ApEinfo_label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5831..5840 /label=attL2 /ApEinfo_fwdcolor=#ff0000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 6564..6632 /label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1732..2328 /label=Pac /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 gene 4644..5774 /gene="HDAC8" /gene_synonym="RPD3" /db_xref="GeneID:55869" /db_xref="HGNC:13315" /db_xref="MIM:300269" /label=HDAC8(1) /ApEinfo_label=HDAC8 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_difference 4735..4735 /gene="HDAC8" /gene_synonym="RPD3" /note="'C' in cDNA is 'T' in the human genome; amino acid difference: 'P' in cDNA, 'L' in the human genome. The chimpanzee genome agrees with the human genomic sequence and not the cDNA." /label=HDAC8(2) /ApEinfo_label=HDAC8 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5887..6410 /label=IRES /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature complement(5841..5855) /label=AttR2 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(3..458) /label=M13 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4644..5774 /label=HDAC8(3) /ApEinfo_label=HDAC8 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4644..4807 /label=sequenced /ApEinfo_fwdcolor=#0080ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6412..10354 /label=b-geo /ApEinfo_fwdcolor=#800000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 2335..3330 /label=DeltaTK /ApEinfo_fwdcolor=#0000ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5386..5774 /label=sequenced(1) /ApEinfo_label=sequenced /ApEinfo_fwdcolor=#0080c0 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4446..4551 /label=mCMV promoter /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5265..5385 /label=sequenced(2) /ApEinfo_label=sequenced /ApEinfo_fwdcolor=#004080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4160..4437 /label=8xTetO2 element /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4808..5127 /label=sequenced(3) /ApEinfo_label=sequenced /ApEinfo_fwdcolor=#004080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(135..441) /label=F1 ori /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5238..5264 /label=sequenced(4) /ApEinfo_label=sequenced /ApEinfo_fwdcolor=#004080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3685..3926 /label=chicken 5'-HS4 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5128..5159 /label=sequenced(5) /ApEinfo_label=sequenced /ApEinfo_fwdcolor=#004080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 602..619 /label=M13-fwd /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6475..9500 /label=LacZ /ApEinfo_fwdcolor=#00ffff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10355..10661 /label=pA /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4563..4570 /label=AttR1 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10779..11049 /label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(11239..11258) /label=T3 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(463..531) /label=LacZ alpha(1) /ApEinfo_label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(11276..11296) /label=M13-rev /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 707..941 /label=PB 3'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(11664..12346) /label=ColE1 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_binding complement(11302..11324) /label=LacO /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(12444..13103) /label=AmpR /ApEinfo_fwdcolor=yellow /ApEinfo_revcolor=yellow /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 11050..11091 /label=PB 5'LTR(1) /ApEinfo_label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 ORIGIN 1 GGAAATTGTA AACGTTAATA TTTTGTTAAA ATTCGCGTTA AATTTTTGTT AAATCAGCTC 61 ATTTTTTAAC CAATAGGCCG AAATCGGCAA AATCCCTTAT AAATCAAAAG AATAGACCGA 121 GATAGGGTTG AGTGTTGTTC CAGTTTGGAA CAAGAGTCCA CTATTAAAGA ACGTGGACTC 181 CAACGTCAAA GGGCGAAAAA CCGTCTATCA GGGCGATGGC CCACTACGTG AACCATCACC 241 CTAATCAAGT TTTTTGGGGT CGAGGTGCCG TAAAGCACTA AATCGGAACC CTAAAGGGAG 301 CCCCCGATTT AGAGCTTGAC GGGGAAAGCC GGCGAACGTG GCGAGAAAGG AAGGGAAGAA 361 AGCGAAAGGA GCGGGCGCTA GGGCGCTGGC AAGTGTAGCG GTCACGCTGC GCGTAACCAC 421 CACACCCGCC GCGCTTAATG CGCCGCTACA GGGCGCGTCG CGCCATTCGC CATTCAGGCT 481 GCGCAACTGT TGGGAAGGGC GATCGGTGCG GGCCTCTTCG CTATTACGCC AGCTGGCGAA 541 AGGGGGATGT GCTGCAAGGC GATTAAGTTG GGTAACGCCA GGGTTTTCCC AGTCACGACG 601 TTGTAAAACG ACGGCCAGTG AATTGTAATA CGACTCACTA TAGGGCGAAT TGGAGCTCGG 661 TATTCACGAC AGCAGGCTGA ATAATAAAAA AATTAGAAAC TATTATttaa ccctagaaag 721 ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc atgtgtttta 781 tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt tattatattt 841 acacttacat actaataata aattcaacaa acaatttatt tatgtttatt tatttattaa 901 aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttaAA CATTCTCTCT 961 TTTACAAAAA TAAACTTATT TTGTACTTTA AAAACAGTCA TGTTGTATTA TAAAATAAGT 1021 AATTAGCTTA ACCTATACAT AATAGAAACA AATTATACTT ATTAGTCAGT CAGAAACAAC 1081 TTTGGCACAT ATCAATATTA TGCTCTCGTT ACTGGCGAAA GGGGGATGTG CTGCAAGGCG 1141 ATTAAGTTGG GTAACGCCAG GGTTTTCCCA GTCACGACGT TGTAAAACGA CGGCCAGTGA 1201 ATTCtaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc 1261 cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac 1321 cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc 1381 cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga 1441 agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt 1501 aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct 1561 gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg 1621 aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt 1681 ctcctcttcc tcatctccgg gcctttcgac cGATCATCAA GCTTGATCCT Catgaccgag 1741 tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccAgggccgt acgcaccctc 1801 gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgaTccgga ccgccacatc 1861 gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag 1921 gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa 1981 gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg 2041 gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg 2101 ttcctggcca ccgtcggcgt ctcgcccgac caccagggca agggtctggg cagcgccgtc 2161 gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacctcc 2221 gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag 2281 Gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgccgg atccATGCCC 2341 ACGCTACTGC GGGTTTATAT AGACGGTCCC CACGGGATGG GGAAAACCAC CACCACGCAA 2401 CTGCTGGTGG CCCTGGGTTC GCGCGACGAT ATCGTCTACG TACCCGAGCC GATGACTTAC 2461 TGGCGGGTGc TGGGGGCTTC CGAGACAATC GCGAACATCT ACACCACACA ACACCGCCTC 2521 GACCAGGGTG AGATATCGGC CGGGGACGCG GCGGTGGTAA TGACAAGCGC CCAGATAACA 2581 ATGGGCATGC CTTATGCCGT GACCGACGCC GTTCTGGCTC CTCATATCGG GGGGGAGGCT 2641 GGGAGCTCAC ATGCCCCGCC CCCGGCCCTC ACCCTCATCT TCGACCGCCA TCCCATCGCC 2701 GCCCTCCTGT GCTACCCGGC CGCGCGgTAC CTTATGGGCA GCATGACCCC CCAGGCCGTG 2761 CTGGCGTTCG TGGCCCTCAT CCCGCCGACC TTGCCCGGCA CcAACATCGT GcTTGGGGCC 2821 CTTCCGGAGG ACAGACACAT CGACCGCCTG GCCAAACGCC AGCGCCCCGG CGAGCGGCTg 2881 GACCTGGCTA TGCTGGCtGC GATTCGCCGC GTTTAcGGGC TaCTTGCCAA TACGGTGCGG 2941 TATCTGCAGt GCGGCGGGTC GTGGCGGGAG GAcTGGGGAC AGCTTTCGGG GaCGGCCGTG 3001 CCGCCCCAGG GTGCCGAGCC CCAGAGCAAC GCGGGCCCAC GACCCCATAT CGGGGACACG 3061 TTATTTACCC TGTTTCGGGC CCCCGAGTTG CTGGCCCCCA ACGGCGACCT GTATAACGTG 3121 TTTGCCTGGG CcTTGGACGT CTTGGCCAAA CGCCTCCGTT CCATGCACGT CTTTATCCTG 3181 GATTACGACC AATCGCCCGC CGGCTGCCGG GACGCCCTGC TGCAACTTAC CTCCGGGATG 3241 GTCCAGACCC ACGTCACCAC CCCCGGCTCC ATACCGACGA TATGCGACCT GGCGCGCACG 3301 TTTGCCCGGG AGATGGGGGA GGCTAACTGA gctctagctt atcgactcgc cgatagtgga 3361 aaccgacgcc ccagcactcg tccgagggca aaggaatagt cgagaaattg atgatctatt 3421 aaacaataaa gatgtccaca tggaagtttt tcctgtcata ctttgttaag aagggtgaga 3481 acagagtacc tacattttga atggaaggat tggagctacg ggggtggggg tggggtggga 3541 ttagataaat gcctgctctt tactgaaggc tctttactat tgctttatga taatgtttca 3601 tagttggata tcataattta aacaagcaaa accaaattaa gggccagctc attcctccca 3661 ctcatgatct atagatccTc tagaGAGCTC ACGGGGACAG CCCCCCCCCA AAGCCCCCAG 3721 GGATGTAATT ACGTCCCTCC CCCGCTAGGG GGCAGCAGCG AGCCGCCCGG GGCTCCGCTC 3781 CGGTCCGGCG CTCCCCCCGC ATCCCCGAGC CGGCAGCGTG CGGGGACAGC CCGGGCACGG 3841 GGAAGGTGGC ACGGGATCGC TTTCCTCTGA ACGCTTCTCG CTGCTCTTTG AGCCTGCAGA 3901 CACCTGGGGG ATACGGGGAA AAAGCTgtcg aCCTGCAGGC ATGCAAGCTT GGCGTAATCA 3961 TGGTCATAGC TGTTTCCTGT GTGAAATTGT TATCCGCTCA CAATTCCACA CAACATACGA 4021 GCCGGAAGCA TAAAGTGTAA AGCCTGGGGT GCCTAATGAG TGAGCTAACT CACATTAATT 4081 GCGTTGCGCT CACTGCCCGC TTTCCAGTCG GGAAACCTGT CGTGCCAGTA ACTCGAGGGA 4141 TCCAAGCTgg CCgcACGTCT CCCTATCAGT GATAGAGAAG TCGACACGTC TCGAGCTCCC 4201 TATCAGTGAT AGAGAAGGTA CGTCTAGAAC GTCTCCCTAT CAGTGATAGA GAAGTCGACA 4261 CGTCTCGAGC TCCCTATCAG TGATAGAGAA GGTACGTCTA GAACGTCTCC CTATCAGTGA 4321 TAGAGAAGTC GACACGTCTC GAGCTCCCTA TCAGTGATAG AGAAGGTACG TCTAGAACGT 4381 CTCCCTATCA GTGATAGAGA AGTCGACACG TCTCGAGCTC CCTATCAGTG ATAGAGAAGG 4441 TACCCCCTAT ATAAGCAGAG CTCGTTTAGT GAACCGTCAG ATCGCCTGGA GACGCCATCC 4501 ACGCTGTTTT GACCTCCATA GAAGACACCG GGACCGATCC AGCCTCCGCG GTGGCGGCCA 4561 TCACAAGTTT GTACAAAAAA GCAGGCTCCG CGGCCGCCCC CTTCACCGCT AGGGATAACA 4621 GGGTAATAGA AGGAGCCGCC ACCatggagg agccggagga accggcggac agtgggcagt 4681 cgctggtccc ggtttatatc tatagtcccg agtatgtcag tatgtgtgac tccccggcca 4741 agatccccaa acgggccagt atggtgcatt ctttgattga agcatatgca ctgcataagc 4801 aaatgaggat agttaagcct aaagtggcct ccatggagga gatggccacc ttccacactg 4861 atgcttatct gcagcatctc cagaaggtca gccaagaggg cgatgatgat catccggact 4921 ccatagaata tgggctaggt tatgactgcc cagccactga agggatattt gactatgcag 4981 cagctatagg aggggctacg atcacagctg cccaatgcct gattgacgga atgtgcaaag 5041 tagcaattaa ctggtctgga gggtggcatc atgcaaagaa agatgaagca tctggttttt 5101 gttatctcaa tgatgctgtc ctgggaatat tacgattgcg acggaaattt gagcgtattc 5161 tctacgtgga tttggatctg caccatggag atggtgtaga agacgcattc agtttcacct 5221 ccaaagtcat gaccgtgtcc ctgcacaaat tctccccagg atttttccca ggaacaggtg 5281 acgtgtctga tgttggccta gggaagggac ggtactacag tgtaaatgtg cccattcagg 5341 atggcataca agatgaaaaa tattaccaga tctgtgaaag tgtactaaag gaagtatacc 5401 aagcctttaa tcccaaagca gtggtcttac agctgggagc tgacacaata gctggggatc 5461 ccatgtgctc ctttaacatg actccagtgg gaattggcaa gtgtcttaag tacatccttc 5521 aatggcagtt ggcaacactc attttgggag gaggaggcta taaccttgcc aacacggctc 5581 gatgctggac atacttgacc ggggtcatcc tagggaaaac actatcctct gagatcccag 5641 atcatgagtt tttcacagca tatggtcctg attatgtgct ggaaatcacg ccaagctgcc 5701 ggccagaccg caatgagccc caccgaatcc aacaaatcct caactacatc aaagggaatc 5761 tgaagcatgt ggtcTGAGTT TCCTGTGAAC AATTGCTCCT CTCTTAAGGT AGCAAAGGGT 5821 GGGCGCGCCG ACCCAGCTTT CTTGTACAAA GTGGTGATgg ccGCTCTAGC TAGTCGATAA 5881 GCTAATTCCG CCCCCCCCCC CCCCCCCCCC TCACCcTCCC CCCCCCctaa cgttactggc 5941 cgaagccgct tggaataagg ccggtgagcg tttgtctata tgttattttc caccatattg 6001 ccgtcttttg gcaatgtgag ggcccgaaac ctggccctgt cttcttgacg acgattccta 6061 ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag 6121 ttcctctgga agcttcttga agacaacaac gtctgtagcg accctttgca ggcagcggaa 6181 ccccccacct ggcgacatgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat 6241 tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc 6301 ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaacgtctag gccccccgaa 6361 ccacggggac gtggttttgg tttgaaaaac acgatgataa tatggccaca accatggaac 6421 agggggatca gcttaccatg gccaagatcc ctcctaagaa gaagcgcaaa gtcgaggatc 6481 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6541 cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6601 cccaacagtt gcgcagcctg aatggcgaat ggcgctttgc ctggtttccg gcaccagaag 6661 cggtgccgga aagctggctg gagtgcgatc ttcctgaggc cgatactgtc gtcgtcccct 6721 caaactggca gatgcacggt tacgatgcgc ccatctacac caacgtaacc tatcccatta 6781 cggtcaatcc gccgtttgtt cccacggaga atccgacggg ttgttactcg ctcacattta 6841 atgttgatga aagctggcta caggaaggcc agacgcgaat tatttttgat ggcgttaact 6901 cggcgtttca tctgtggtgc aacgggcgct gggtcggtta cggccaggac agtcgtttgc 6961 cgtctgaatt tgacctgagc gcatttttac gcgccggaga aaaccgcctc gcggtgatgg 7021 tgctgcgttg gagtgacggc agttatctgg aagatcagga tatgtggcgg atgagcggca 7081 ttttccgtga cgtctcgttg ctgcataaac cgactacaca aatcagcgat ttccatgttg 7141 ccactcgctt taatgatgat ttcagccgcg ctgtactgga ggctgaagtt cagatgtgcg 7201 gcgagttgcg tgactaccta cgggtaacag tttctttatg gcagggtgaa acgcaggtcg 7261 ccagcggcac cgcgcctttc ggcggtgaaa ttatcgatga gcgtggtggt tatgccgatc 7321 gcgtcacact acgtctgaac gtcgaaaacc cgaaactgtg gagcgccgaa atcccgaatc 7381 tctatcgtgc ggtggttgaa ctgcacaccg ccgacggcac gctgattgaa gcagaagcct 7441 gcgatgtcgg tttccgcgag gtgcggattg aaaatggtct gctgctgctg aacggcaagc 7501 cgttgctgat tcgaggcgtt aaccgtcacg agcatcatcc tctgcatggt caggtcatgg 7561 atgagcagac gatggtgcag gatatcctgc tgatgaagca gaacaacttt aacgccgtgc 7621 gctgttcgca ttatccgaac catccgctgt ggtacacgct gtgcgaccgc tacggcctgt 7681 atgtggtgga tgaagccaat attgaaaccc acggcatggt gccaatgaat cgtctgaccg 7741 atgatccgcg ctggctaccg gcgatgagcg aacgcgtaac gcgaatggtg cagcgcgatc 7801 gtaatcaccc gagtgtgatc atctggtcgc tggggaatga atcaggccac ggcgctaatc 7861 acgacgcgct gtatcgctgg atcaaatctg tcgatccttc ccgcccggtg cagtatgaag 7921 gcggcggagc cgacaccacg gccaccgata ttatttgccc gatgtacgcg cgcgtggatg 7981 aagaccagcc cttcccggct gtgccgaaat ggtccatcaa aaaatggctt tcgctacctg 8041 gagagacgcg cccgctgatc ctttgcgaat acgcccacgc gatgggtaac agtcttggcg 8101 gtttcgctaa atactggcag gcgtttcgtc agtatccccg tttacagggc ggcttcgtct 8161 gggactgggt ggatcagtcg ctgattaaat atgatgaaaa cggcaacccg tggtcggctt 8221 acggcggtga ttttggcgat acgccgaacg atcgccagtt ctgtatgaac ggtctggtct 8281 ttgccgaccg cacgccgcat ccagcgctga cggaagcaaa acaccagcag cagtttttcc 8341 agttccgttt atccgggcaa accatcgaag tgaccagcga atacctgttc cgtcatagcg 8401 ataacgagct cctgcactgg atggtggcgc tggatggtaa gccgctggca agcggtgaag 8461 tgcctctgga tgtcgctcca caaggtaaac agttgattga actgcctgaa ctaccgcagc 8521 cggagagcgc cgggcaactc tggctcacag tacgcgtagt gcaaccgaac gcgaccgcat 8581 ggtcagaagc cgggcacatc agcgcctggc agcagtggcg tctggcggaa aacctcagtg 8641 tgacgctccc cgccgcgtcc cacgccatcc cgcatctgac caccagcgaa atggattttt 8701 gcatcgagct gggtaataag cgttggcaat ttaaccgcca gtcaggcttt ctttcacaga 8761 tgtggattgg cgataaaaaa caactgctga cgccgctgcg cgatcagttc acccgtgcac 8821 cgctggataa cgacattggc gtaagtgaag cgacccgcat tgaccctaac gcctgggtcg 8881 aacgctggaa ggcggcgggc cattaccagg ccgaagcagc gttgttgcag tgcacggcag 8941 atacacttgc tgatgcggtg ctgattacga ccgctcacgc gtggcagcat caggggaaaa 9001 ccttatttat cagccggaaa acctaccgga ttgatggtag tggtcaaatg gcgattaccg 9061 ttgatgttga agtggcgagc gatacaccgc atccggcgcg gattggcctg aactgccagc 9121 tggcgcaggt agcagagcgg gtaaactggc tcggattagg gccgcaagaa aactatcccg 9181 accgccttac tgccgcctgt tttgaccgct gggatctgcc attgtcagac atgtataccc 9241 cgtacgtctt cccgagcgaa aacggtctgc gctgcgggac gcgcgaattg aattatggcc 9301 cacaccagtg gcgcggcgac ttccagttca acatcagccg ctacagtcaa cagcaactga 9361 tggaaaccag ccatcgccat ctgctgcacg cggaagaagg cacatggctg aatatcgacg 9421 gtttccatat ggggattggt ggcgacgact cctggagccc gtcagtatcg gcggaattcc 9481 agctgagcgc cggtcgctac cattaccagt tggtctggtg tcaggggatc ccccgggctg 9541 cagccaatat gggatcggcc attgaacaag atggattgca cgcaggttct ccggccgctt 9601 gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg 9661 ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg 9721 gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg 9781 ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg 9841 gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca 9901 tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc 9961 accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc 10021 aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca 10081 aggcgcgcat gcccgacggc gatgatctcg tcgtgaccca tggcgatgcc tgcttgccga 10141 atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg 10201 cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg 10261 aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg 10321 ccttctatcg ccttcttgac gagttcttct gaggggatca attctctagg gctcgctgat 10381 cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt 10441 ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat 10501 cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg 10561 gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg 10621 aggcggaaag aaccagctgg ggctcgatcc tctagagtcg aGGGCTGCAG GAATTCGATA 10681 TCAAGCTCTA GCCAACAAGC TCGTCATCGC TTTGCAGAAG AGCAGAGAGG ATATGCTCAT 10741 CGTCTAAAGA ACTACCCATT TTATTATATA TTAGTCACga tatctataac aagaaaatat 10801 atatataata agttatcacg taagtagaac atgaaataac aatataatta tcgtatgagt 10861 taaatcttaa aagtcacgta aaagataatc atgcgtcatt ttgactcacg cggtcgttat 10921 agttcaaaat cagtgacact taccgcattg acaagcacgc ctcacgggag ctccaagcgg 10981 cgactgagat gtcctaaatg cacagcgacg gattcgcgct atttagaaag agagagcaat 11041 atttcaagaA TGCATgcgtc aattttacgc agactatctt tctagggtta aAtttAAAtG 11101 ATTTGCGCTT TACTCGACCT AAACTTTAAA CACGTCATAG AATCTTCGTT TGACAAAAAC 11161 CACATTGTGG CCAAGCTGTG TGACGCGACG CGCGCTAAAG AATGGCAAAC CAAGTCGCGC 11221 GAGGTACCCA GCTTTTGTTC CCTTTAGTGA GGGTTAATTC CGAGCTTGGC GTAATCATGG 11281 TCATAGCTGT TTCCTGTGTG AAATTGTTAT CCGCTCACAA TTCCACACAA CATACGAGCC 11341 GGAAGCATAA AGTGTAAAGC CTGGGGTGCC TAATGAGTGA GCTAACTCAC ATTAATTGCG 11401 TTGCGCTCAC TGCCCGCTTT CCAGTCGGGA AACCTGTCGT GCCAGCTGCA TTAATGAATC 11461 GGCCAACGCG CGGGGAGAGG CGGTTTGCGT ATTGGGCGCT CTTCCGCTTC CTCGCTCACT 11521 GACTCGCTGC GCTCGGTCGT TCGGCTGCGG CGAGCGGTAT CAGCTCACTC AAAGGCGGTA 11581 ATACGGTTAT CCACAGAATC AGGGGATAAC GCAGGAAAGA ACATGTGAGC AAAAGGCCAG 11641 CAAAAGGCCA GGAACCGTAA AAAGGCCGCG TTGCTGGCGT TTTTCCATAG GCTCCGCCCC 11701 CCTGACGAGC ATCACAAAAA TCGACGCTCA AGTCAGAGGT GGCGAAACCC GACAGGACTA 11761 TAAAGATACC AGGCGTTTCC CCCTGGAAGC TCCCTCGTGC GCTCTCCTGT TCCGACCCTG 11821 CCGCTTACCG GATACCTGTC CGCCTTTCTC CCTTCGGGAA GCGTGGCGCT TTCTCATAGC 11881 TCACGCTGTA GGTATCTCAG TTCGGTGTAG GTCGTTCGCT CCAAGCTGGG CTGTGTGCAC 11941 GAACCCCCCG TTCAGCCCGA CCGCTGCGCC TTATCCGGTA ACTATCGTCT TGAGTCCAAC 12001 CCGGTAAGAC ACGACTTATC GCCACTGGCA GCAGCCACTG GTAACAGGAT TAGCAGAGCG 12061 AGGTATGTAG GCGGTGCTAC AGAGTTCTTG AAGTGGTGGC CTAACTACGG CTACACTAGA 12121 AGGACAGTAT TTGGTATCTG CGCTCTGCTG AAGCCAGTTA CCTTCGGAAA AAGAGTTGGT 12181 AGCTCTTGAT CCGGCAAACA AACCACCGCT GGTAGCGGTG GTTTTTTTGT TTGCAAGCAG 12241 CAGATTACGC GCAGAAAAAA AGGATCTCAA GAAGATCCTT TGATCTTTTC TACGGGGTCT 12301 GACGCTCAGT GGAACGAAAA CTCACGTTAA GGGATTTTGG TCATGAGATT ATCAAAAAGG 12361 ATCTTCACCT AGATCCTTTT AAATTAAAAA TGAAGTTTTA AATCAATCTA AAGTATATAT 12421 GAGTAAACTT GGTCTGACAG TTACCAATGC TTAATCAGTG AGGCACCTAT CTCAGCGATC 12481 TGTCTATTTC GTTCATCCAT AGTTGCCTGA CTCCCCGTCG TGTAGATAAC TACGATACGG 12541 GAGGGCTTAC CATCTGGCCC CAGTGCTGCA ATGATACCGC GAGACCCACG CTCACCGGCT 12601 CCAGATTTAT CAGCAATAAA CCAGCCAGCC GGAAGGGCCG AGCGCAGAAG TGGTCCTGCA 12661 ACTTTATCCG CCTCCATCCA GTCTATTAAT TGTTGCCGGG AAGCTAGAGT AAGTAGTTCG 12721 CCAGTTAATA GTTTGCGCAA CGTTGTTGCC ATTGCTACAG GCATCGTGGT GTCACGCTCG 12781 TCGTTTGGTA TGGCTTCATT CAGCTCCGGT TCCCAACGAT CAAGGCGAGT TACATGATCC 12841 CCCATGTTGT GCAAAAAAGC GGTTAGCTCC TTCGGTCCTC CGATCGTTGT CAGAAGTAAG 12901 TTGGCCGCAG TGTTATCACT CATGGTTATG GCAGCACTGC ATAATTCTCT TACTGTCATG 12961 CCATCCGTAA GATGCTTTTC TGTGACTGGT GAGTACTCAA CCAAGTCATT CTGAGAATAG 13021 TGTATGCGGC GACCGAGTTG CTCTTGCCCG GCGTCAATAC GGGATAATAC CGCGCCACAT 13081 AGCAGAACTT TAAAAGTGCT CATCATTGGA AAACGTTCTT CGGGGCGAAA ACTCTCAAGG 13141 ATCTTACCGC TGTTGAGATC CAGTTCGATG TAACCCACTC GTGCACCCAA CTGATCTTCA 13201 GCATCTTTTA CTTTCACCAG CGTTTCTGGG TGAGCAAAAA CAGGAAGGCA AAATGCCGCA 13261 AAAAAGGGAA TAAGGGCGAC ACGGAAATGT TGAATACTCA TACTCTTCCT TTTTCAATAT 13321 TATTGAAGCA TTTATCAGGG TTATTGTCTC ATGAGCGGAT ACATATTTGA ATGTATTTAG 13381 AAAAATAAAC AAATAGGGGT TCCGCGCACA TTTCCCCGAA AAGTGCCACC TG //