LOCUS 91188_PB_tet_PHS 13682 bp ds-DNA circular 25-JUL-2013 DEFINITION . ACCESSION VERSION SOURCE . ORGANISM . COMMENT Insert from pORF-NR5A2 652 to 2171 COMMENT Backbone from 90946 PB-tet-PH-lox66FRT2 6253 to 4570 COMMENT ApEinfo:methylated:1 FEATURES Location/Qualifiers misc_feature 4588..4592 /label=kozak /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1205..1459 /label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 source 4593..6080 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1q32.1" /label=source:Homo sapiens /ApEinfo_fwdcolor=#ffffff /ApEinfo_revcolor=#ffffff /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3331..3678 /label=polyA /ApEinfo_fwdcolor=#ff8080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5565..5684 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /inference="alignment:Splign:1.39.8" /number=7 /label=NR5A2 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 602..619 /label=M13-fwd /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 gene 4593..6080 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /note="nuclear receptor subfamily 5, group A, member 2" /db_xref="GeneID:2494" /db_xref="HGNC:7984" /db_xref="MIM:604453" /label=NR5A2(1) /ApEinfo_label=NR5A2 /ApEinfo_fwdcolor=#ff0080 /ApEinfo_revcolor=#004080 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1460..1711 /label=mouse PGK promoter(1) /ApEinfo_label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5685..5832 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /inference="alignment:Splign:1.39.8" /number=8 /label=NR5A2(2) /ApEinfo_label=NR5A2 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 6814..6882 /label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 618..645 /label=T7 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4593..4656 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /inference="alignment:Splign:1.39.8" /number=1 /label=NR5A2(3) /ApEinfo_label=NR5A2 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1732..2328 /label=Pac /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5833..6080 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /inference="alignment:Splign:1.39.8" /number=9 /label=NR5A2(4) /ApEinfo_label=NR5A2 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6137..6660 /label=IRES /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 4593..6080 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /note="isoform 2 is encoded by transcript variant 2; CYP7A promoter-binding factor; liver receptor homolog 1; fetoprotein-alpha 1 (AFP) transcription factor; liver receptor homolog-1; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; liver nuclear receptor homolog-1 variant 2; nuclear receptor NR5A2; hepatocytic transcription factor; alpha-1-fetoprotein transcription factor" /codon_start=1 /product="nuclear receptor subfamily 5 group A member 2 isoform 2" /protein_id="NP_003813.1" /db_xref="GI:4504343" /db_xref="CCDS:CCDS1400.1" /db_xref="GeneID:2494" /db_xref="HGNC:7984" /db_xref="MIM:604453" /translation="MSSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCG DKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLS VGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSD LTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHF PSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKI MAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQN CWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKL RSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKF GQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA" /label=nuclear receptor subfamily 5 group A member 2 isof /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=#ffff80 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4657..4775 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /inference="alignment:Splign:1.39.8" /number=4 /label=NR5A2(5) /ApEinfo_label=NR5A2 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature complement(6091..6105) /label=AttR2 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(135..441) /label=F1 ori /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4571..4587 /label=attL1 /ApEinfo_fwdcolor=#ff80c0 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4446..4551 /label=mCMV promoter /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4776..4917 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /inference="alignment:Splign:1.39.8" /number=5 /label=NR5A2(6) /ApEinfo_label=NR5A2 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4160..4437 /label=8xTetO2 element /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6081..6090 /label=attL2 /ApEinfo_fwdcolor=#ff80ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6662..10604 /label=b-geo /ApEinfo_fwdcolor=#800000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(3..458) /label=M13 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4918..5564 /gene="NR5A2" /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1" /inference="alignment:Splign:1.39.8" /number=6 /label=NR5A2(7) /ApEinfo_label=NR5A2 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3685..3926 /label=chicken 5'-HS4 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6725..9750 /label=LacZ /ApEinfo_fwdcolor=#00ffff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 2335..3330 /label=DeltaTK /ApEinfo_fwdcolor=#0000ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10605..10911 /label=pA /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 11029..11299 /label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4563..4570 /label=AttR1 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(11489..11508) /label=T3 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(11526..11546) /label=M13-rev /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(463..531) /label=LacZ alpha(1) /ApEinfo_label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(11914..12596) /label=ColE1 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 707..941 /label=PB 3'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_binding complement(11552..11574) /label=LacO /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(12694..13353) /label=AmpR /ApEinfo_fwdcolor=yellow /ApEinfo_revcolor=yellow /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 11300..11341 /label=PB 5'LTR(1) /ApEinfo_label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 ORIGIN 1 GGAAATTGTA AACGTTAATA TTTTGTTAAA ATTCGCGTTA AATTTTTGTT AAATCAGCTC 61 ATTTTTTAAC CAATAGGCCG AAATCGGCAA AATCCCTTAT AAATCAAAAG AATAGACCGA 121 GATAGGGTTG AGTGTTGTTC CAGTTTGGAA CAAGAGTCCA CTATTAAAGA ACGTGGACTC 181 CAACGTCAAA GGGCGAAAAA CCGTCTATCA GGGCGATGGC CCACTACGTG AACCATCACC 241 CTAATCAAGT TTTTTGGGGT CGAGGTGCCG TAAAGCACTA AATCGGAACC CTAAAGGGAG 301 CCCCCGATTT AGAGCTTGAC GGGGAAAGCC GGCGAACGTG GCGAGAAAGG AAGGGAAGAA 361 AGCGAAAGGA GCGGGCGCTA GGGCGCTGGC AAGTGTAGCG GTCACGCTGC GCGTAACCAC 421 CACACCCGCC GCGCTTAATG CGCCGCTACA GGGCGCGTCG CGCCATTCGC CATTCAGGCT 481 GCGCAACTGT TGGGAAGGGC GATCGGTGCG GGCCTCTTCG CTATTACGCC AGCTGGCGAA 541 AGGGGGATGT GCTGCAAGGC GATTAAGTTG GGTAACGCCA GGGTTTTCCC AGTCACGACG 601 TTGTAAAACG ACGGCCAGTG AATTGTAATA CGACTCACTA TAGGGCGAAT TGGAGCTCGG 661 TATTCACGAC AGCAGGCTGA ATAATAAAAA AATTAGAAAC TATTATttaa ccctagaaag 721 ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc atgtgtttta 781 tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt tattatattt 841 acacttacat actaataata aattcaacaa acaatttatt tatgtttatt tatttattaa 901 aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttaAA CATTCTCTCT 961 TTTACAAAAA TAAACTTATT TTGTACTTTA AAAACAGTCA TGTTGTATTA TAAAATAAGT 1021 AATTAGCTTA ACCTATACAT AATAGAAACA AATTATACTT ATTAGTCAGT CAGAAACAAC 1081 TTTGGCACAT ATCAATATTA TGCTCTCGTT ACTGGCGAAA GGGGGATGTG CTGCAAGGCG 1141 ATTAAGTTGG GTAACGCCAG GGTTTTCCCA GTCACGACGT TGTAAAACGA CGGCCAGTGA 1201 ATTCtaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc 1261 cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac 1321 cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc 1381 cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga 1441 agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt 1501 aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct 1561 gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg 1621 aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt 1681 ctcctcttcc tcatctccgg gcctttcgac cGATCATCAA GCTTGATCCT Catgaccgag 1741 tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccAgggccgt acgcaccctc 1801 gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgaTccgga ccgccacatc 1861 gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag 1921 gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa 1981 gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg 2041 gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg 2101 ttcctggcca ccgtcggcgt ctcgcccgac caccagggca agggtctggg cagcgccgtc 2161 gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacctcc 2221 gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag 2281 Gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgccgg atccATGCCC 2341 ACGCTACTGC GGGTTTATAT AGACGGTCCC CACGGGATGG GGAAAACCAC CACCACGCAA 2401 CTGCTGGTGG CCCTGGGTTC GCGCGACGAT ATCGTCTACG TACCCGAGCC GATGACTTAC 2461 TGGCGGGTGc TGGGGGCTTC CGAGACAATC GCGAACATCT ACACCACACA ACACCGCCTC 2521 GACCAGGGTG AGATATCGGC CGGGGACGCG GCGGTGGTAA TGACAAGCGC CCAGATAACA 2581 ATGGGCATGC CTTATGCCGT GACCGACGCC GTTCTGGCTC CTCATATCGG GGGGGAGGCT 2641 GGGAGCTCAC ATGCCCCGCC CCCGGCCCTC ACCCTCATCT TCGACCGCCA TCCCATCGCC 2701 GCCCTCCTGT GCTACCCGGC CGCGCGgTAC CTTATGGGCA GCATGACCCC CCAGGCCGTG 2761 CTGGCGTTCG TGGCCCTCAT CCCGCCGACC TTGCCCGGCA CcAACATCGT GcTTGGGGCC 2821 CTTCCGGAGG ACAGACACAT CGACCGCCTG GCCAAACGCC AGCGCCCCGG CGAGCGGCTg 2881 GACCTGGCTA TGCTGGCtGC GATTCGCCGC GTTTAcGGGC TaCTTGCCAA TACGGTGCGG 2941 TATCTGCAGt GCGGCGGGTC GTGGCGGGAG GAcTGGGGAC AGCTTTCGGG GaCGGCCGTG 3001 CCGCCCCAGG GTGCCGAGCC CCAGAGCAAC GCGGGCCCAC GACCCCATAT CGGGGACACG 3061 TTATTTACCC TGTTTCGGGC CCCCGAGTTG CTGGCCCCCA ACGGCGACCT GTATAACGTG 3121 TTTGCCTGGG CcTTGGACGT CTTGGCCAAA CGCCTCCGTT CCATGCACGT CTTTATCCTG 3181 GATTACGACC AATCGCCCGC CGGCTGCCGG GACGCCCTGC TGCAACTTAC CTCCGGGATG 3241 GTCCAGACCC ACGTCACCAC CCCCGGCTCC ATACCGACGA TATGCGACCT GGCGCGCACG 3301 TTTGCCCGGG AGATGGGGGA GGCTAACTGA gctctagctt atcgactcgc cgatagtgga 3361 aaccgacgcc ccagcactcg tccgagggca aaggaatagt cgagaaattg atgatctatt 3421 aaacaataaa gatgtccaca tggaagtttt tcctgtcata ctttgttaag aagggtgaga 3481 acagagtacc tacattttga atggaaggat tggagctacg ggggtggggg tggggtggga 3541 ttagataaat gcctgctctt tactgaaggc tctttactat tgctttatga taatgtttca 3601 tagttggata tcataattta aacaagcaaa accaaattaa gggccagctc attcctccca 3661 ctcatgatct atagatccTc tagaGAGCTC ACGGGGACAG CCCCCCCCCA AAGCCCCCAG 3721 GGATGTAATT ACGTCCCTCC CCCGCTAGGG GGCAGCAGCG AGCCGCCCGG GGCTCCGCTC 3781 CGGTCCGGCG CTCCCCCCGC ATCCCCGAGC CGGCAGCGTG CGGGGACAGC CCGGGCACGG 3841 GGAAGGTGGC ACGGGATCGC TTTCCTCTGA ACGCTTCTCG CTGCTCTTTG AGCCTGCAGA 3901 CACCTGGGGG ATACGGGGAA AAAGCTgtcg aCCTGCAGGC ATGCAAGCTT GGCGTAATCA 3961 TGGTCATAGC TGTTTCCTGT GTGAAATTGT TATCCGCTCA CAATTCCACA CAACATACGA 4021 GCCGGAAGCA TAAAGTGTAA AGCCTGGGGT GCCTAATGAG TGAGCTAACT CACATTAATT 4081 GCGTTGCGCT CACTGCCCGC TTTCCAGTCG GGAAACCTGT CGTGCCAGTA ACTCGAGGGA 4141 TCCAAGCTgg CCgcACGTCT CCCTATCAGT GATAGAGAAG TCGACACGTC TCGAGCTCCC 4201 TATCAGTGAT AGAGAAGGTA CGTCTAGAAC GTCTCCCTAT CAGTGATAGA GAAGTCGACA 4261 CGTCTCGAGC TCCCTATCAG TGATAGAGAA GGTACGTCTA GAACGTCTCC CTATCAGTGA 4321 TAGAGAAGTC GACACGTCTC GAGCTCCCTA TCAGTGATAG AGAAGGTACG TCTAGAACGT 4381 CTCCCTATCA GTGATAGAGA AGTCGACACG TCTCGAGCTC CCTATCAGTG ATAGAGAAGG 4441 TACCCCCTAT ATAAGCAGAG CTCGTTTAGT GAACCGTCAG ATCGCCTGGA GACGCCATCC 4501 ACGCTGTTTT GACCTCCATA GAAGACACCG GGACCGATCC AGCCTCCGCG GTGGCGGCCA 4561 TCACAAGTTT GTACAAAAAA GCAGGCTcca ccatgtcttc taattcagat actggggatt 4621 tacaagagtc tttaaagcac ggacttacac ctattgtgtc tcaatttaaa atggtgaatt 4681 actcctatga tgaagatctg gaagagcttt gtcccgtgtg tggagataaa gtgtctgggt 4741 accattatgg gctcctcacc tgtgaaagct gcaagggatt ttttaagcga acagtccaaa 4801 ataataaaag gtacacatgt atagaaaacc agaactgcca aattgacaaa acacagagaa 4861 agcgttgtcc ttactgtcgt tttcaaaaat gtctaagtgt tggaatgaag ctagaagctg 4921 taagggccga ccgaatgcgt ggaggaagga ataagtttgg gccaatgtac aagagagaca 4981 gggccctgaa gcaacagaaa aaagccctca tccgagccaa tggacttaag ctagaagcca 5041 tgtctcaggt gatccaagct atgccctctg acctgaccat ttcctctgca attcaaaaca 5101 tccactctgc ctccaaaggc ctacctctga accatgctgc cttgcctcct acagactatg 5161 acagaagtcc ctttgtaaca tcccccatta gcatgacaat gccccctcac ggcagcctgc 5221 aaggttacca aacatatggc cactttccta gccgggccat caagtctgag tacccagacc 5281 cctataccag ctcacccgag tccataatgg gctattcata tatggatagt taccagacga 5341 gctctccagc aagcatccca catctgatac tggaactttt gaagtgtgag ccagatgagc 5401 ctcaagtcca ggctaaaatc atggcctatt tgcagcaaga gcaggctaac cgaagcaagc 5461 acgaaaagct gagcaccttt gggcttatgt gcaaaatggc agatcaaact ctcttctcca 5521 ttgtcgagtg ggccaggagt agtatcttct tcagagaact taaggttgat gaccaaatga 5581 agctgcttca gaactgctgg agtgagctct taatcctcga ccacatttac cgacaagtgg 5641 tacatggaaa ggaaggatcc atcttcctgg ttactgggca acaagtggac tattccataa 5701 tagcatcaca agccggagcc accctcaaca acctcatgag tcatgcacag gagttagtgg 5761 caaaacttcg ttctctccag tttgatcaac gagagttcgt atgtctgaaa ttcttggtgc 5821 tctttagttt agatgtcaaa aaccttgaaa acttccagct ggtagaaggt gtccaggaac 5881 aagtcaatgc cgccctgctg gactacacaa tgtgtaacta cccgcagcag acagagaaat 5941 ttggacagct acttcttcga ctacccgaaa tccgggccat cagtatgcag gctgaagaat 6001 acctctacta caagcacctg aacggggatg tgccctataa taaccttctc attgaaatgt 6061 tgcatgccaa aagagcataa ACCCAGCTTT CTTGTACAAA GTGGTGATgg ccGCTCTAGC 6121 TAGTCGATAA GCTAATTCCG CCCCCCCCCC CCCCCCCCCC TCACCcTCCC CCCCCCctaa 6181 cgttactggc cgaagccgct tggaataagg ccggtgagcg tttgtctata tgttattttc 6241 caccatattg ccgtcttttg gcaatgtgag ggcccgaaac ctggccctgt cttcttgacg 6301 acgattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg 6361 aaggaagcag ttcctctgga agcttcttga agacaacaac gtctgtagcg accctttgca 6421 ggcagcggaa ccccccacct ggcgacatgg atagttgtgg aaagagtcaa atggctctcc 6481 tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct 6541 gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaacgtctag 6601 gccccccgaa ccacggggac gtggttttgg tttgaaaaac acgatgataa tatggccaca 6661 accatggaac agggggatca gcttaccatg gccaagatcc ctcctaagaa gaagcgcaaa 6721 gtcgaggatc ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt 6781 aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc 6841 gatcgccctt cccaacagtt gcgcagcctg aatggcgaat ggcgctttgc ctggtttccg 6901 gcaccagaag cggtgccgga aagctggctg gagtgcgatc ttcctgaggc cgatactgtc 6961 gtcgtcccct caaactggca gatgcacggt tacgatgcgc ccatctacac caacgtaacc 7021 tatcccatta cggtcaatcc gccgtttgtt cccacggaga atccgacggg ttgttactcg 7081 ctcacattta atgttgatga aagctggcta caggaaggcc agacgcgaat tatttttgat 7141 ggcgttaact cggcgtttca tctgtggtgc aacgggcgct gggtcggtta cggccaggac 7201 agtcgtttgc cgtctgaatt tgacctgagc gcatttttac gcgccggaga aaaccgcctc 7261 gcggtgatgg tgctgcgttg gagtgacggc agttatctgg aagatcagga tatgtggcgg 7321 atgagcggca ttttccgtga cgtctcgttg ctgcataaac cgactacaca aatcagcgat 7381 ttccatgttg ccactcgctt taatgatgat ttcagccgcg ctgtactgga ggctgaagtt 7441 cagatgtgcg gcgagttgcg tgactaccta cgggtaacag tttctttatg gcagggtgaa 7501 acgcaggtcg ccagcggcac cgcgcctttc ggcggtgaaa ttatcgatga gcgtggtggt 7561 tatgccgatc gcgtcacact acgtctgaac gtcgaaaacc cgaaactgtg gagcgccgaa 7621 atcccgaatc tctatcgtgc ggtggttgaa ctgcacaccg ccgacggcac gctgattgaa 7681 gcagaagcct gcgatgtcgg tttccgcgag gtgcggattg aaaatggtct gctgctgctg 7741 aacggcaagc cgttgctgat tcgaggcgtt aaccgtcacg agcatcatcc tctgcatggt 7801 caggtcatgg atgagcagac gatggtgcag gatatcctgc tgatgaagca gaacaacttt 7861 aacgccgtgc gctgttcgca ttatccgaac catccgctgt ggtacacgct gtgcgaccgc 7921 tacggcctgt atgtggtgga tgaagccaat attgaaaccc acggcatggt gccaatgaat 7981 cgtctgaccg atgatccgcg ctggctaccg gcgatgagcg aacgcgtaac gcgaatggtg 8041 cagcgcgatc gtaatcaccc gagtgtgatc atctggtcgc tggggaatga atcaggccac 8101 ggcgctaatc acgacgcgct gtatcgctgg atcaaatctg tcgatccttc ccgcccggtg 8161 cagtatgaag gcggcggagc cgacaccacg gccaccgata ttatttgccc gatgtacgcg 8221 cgcgtggatg aagaccagcc cttcccggct gtgccgaaat ggtccatcaa aaaatggctt 8281 tcgctacctg gagagacgcg cccgctgatc ctttgcgaat acgcccacgc gatgggtaac 8341 agtcttggcg gtttcgctaa atactggcag gcgtttcgtc agtatccccg tttacagggc 8401 ggcttcgtct gggactgggt ggatcagtcg ctgattaaat atgatgaaaa cggcaacccg 8461 tggtcggctt acggcggtga ttttggcgat acgccgaacg atcgccagtt ctgtatgaac 8521 ggtctggtct ttgccgaccg cacgccgcat ccagcgctga cggaagcaaa acaccagcag 8581 cagtttttcc agttccgttt atccgggcaa accatcgaag tgaccagcga atacctgttc 8641 cgtcatagcg ataacgagct cctgcactgg atggtggcgc tggatggtaa gccgctggca 8701 agcggtgaag tgcctctgga tgtcgctcca caaggtaaac agttgattga actgcctgaa 8761 ctaccgcagc cggagagcgc cgggcaactc tggctcacag tacgcgtagt gcaaccgaac 8821 gcgaccgcat ggtcagaagc cgggcacatc agcgcctggc agcagtggcg tctggcggaa 8881 aacctcagtg tgacgctccc cgccgcgtcc cacgccatcc cgcatctgac caccagcgaa 8941 atggattttt gcatcgagct gggtaataag cgttggcaat ttaaccgcca gtcaggcttt 9001 ctttcacaga tgtggattgg cgataaaaaa caactgctga cgccgctgcg cgatcagttc 9061 acccgtgcac cgctggataa cgacattggc gtaagtgaag cgacccgcat tgaccctaac 9121 gcctgggtcg aacgctggaa ggcggcgggc cattaccagg ccgaagcagc gttgttgcag 9181 tgcacggcag atacacttgc tgatgcggtg ctgattacga ccgctcacgc gtggcagcat 9241 caggggaaaa ccttatttat cagccggaaa acctaccgga ttgatggtag tggtcaaatg 9301 gcgattaccg ttgatgttga agtggcgagc gatacaccgc atccggcgcg gattggcctg 9361 aactgccagc tggcgcaggt agcagagcgg gtaaactggc tcggattagg gccgcaagaa 9421 aactatcccg accgccttac tgccgcctgt tttgaccgct gggatctgcc attgtcagac 9481 atgtataccc cgtacgtctt cccgagcgaa aacggtctgc gctgcgggac gcgcgaattg 9541 aattatggcc cacaccagtg gcgcggcgac ttccagttca acatcagccg ctacagtcaa 9601 cagcaactga tggaaaccag ccatcgccat ctgctgcacg cggaagaagg cacatggctg 9661 aatatcgacg gtttccatat ggggattggt ggcgacgact cctggagccc gtcagtatcg 9721 gcggaattcc agctgagcgc cggtcgctac cattaccagt tggtctggtg tcaggggatc 9781 ccccgggctg cagccaatat gggatcggcc attgaacaag atggattgca cgcaggttct 9841 ccggccgctt gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc 9901 tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc 9961 gacctgtccg gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc 10021 acgacgggcg ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg 10081 ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag 10141 aaagtatcca tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc 10201 ccattcgacc accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt 10261 cttgtcgatc aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc 10321 gccaggctca aggcgcgcat gcccgacggc gatgatctcg tcgtgaccca tggcgatgcc 10381 tgcttgccga atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg 10441 ctgggtgtgg cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag 10501 cttggcggcg aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg 10561 cagcgcatcg ccttctatcg ccttcttgac gagttcttct gaggggatca attctctagg 10621 gctcgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc 10681 cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag 10741 gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag 10801 gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct 10861 atggcttctg aggcggaaag aaccagctgg ggctcgatcc tctagagtcg aGGGCTGCAG 10921 GAATTCGATA TCAAGCTCTA GCCAACAAGC TCGTCATCGC TTTGCAGAAG AGCAGAGAGG 10981 ATATGCTCAT CGTCTAAAGA ACTACCCATT TTATTATATA TTAGTCACga tatctataac 11041 aagaaaatat atatataata agttatcacg taagtagaac atgaaataac aatataatta 11101 tcgtatgagt taaatcttaa aagtcacgta aaagataatc atgcgtcatt ttgactcacg 11161 cggtcgttat agttcaaaat cagtgacact taccgcattg acaagcacgc ctcacgggag 11221 ctccaagcgg cgactgagat gtcctaaatg cacagcgacg gattcgcgct atttagaaag 11281 agagagcaat atttcaagaA TGCATgcgtc aattttacgc agactatctt tctagggtta 11341 aAtttAAAtG ATTTGCGCTT TACTCGACCT AAACTTTAAA CACGTCATAG AATCTTCGTT 11401 TGACAAAAAC CACATTGTGG CCAAGCTGTG TGACGCGACG CGCGCTAAAG AATGGCAAAC 11461 CAAGTCGCGC GAGGTACCCA GCTTTTGTTC CCTTTAGTGA GGGTTAATTC CGAGCTTGGC 11521 GTAATCATGG TCATAGCTGT TTCCTGTGTG AAATTGTTAT CCGCTCACAA TTCCACACAA 11581 CATACGAGCC GGAAGCATAA AGTGTAAAGC CTGGGGTGCC TAATGAGTGA GCTAACTCAC 11641 ATTAATTGCG TTGCGCTCAC TGCCCGCTTT CCAGTCGGGA AACCTGTCGT GCCAGCTGCA 11701 TTAATGAATC GGCCAACGCG CGGGGAGAGG CGGTTTGCGT ATTGGGCGCT CTTCCGCTTC 11761 CTCGCTCACT GACTCGCTGC GCTCGGTCGT TCGGCTGCGG CGAGCGGTAT CAGCTCACTC 11821 AAAGGCGGTA ATACGGTTAT CCACAGAATC AGGGGATAAC GCAGGAAAGA ACATGTGAGC 11881 AAAAGGCCAG CAAAAGGCCA GGAACCGTAA AAAGGCCGCG TTGCTGGCGT TTTTCCATAG 11941 GCTCCGCCCC CCTGACGAGC ATCACAAAAA TCGACGCTCA AGTCAGAGGT GGCGAAACCC 12001 GACAGGACTA TAAAGATACC AGGCGTTTCC CCCTGGAAGC TCCCTCGTGC GCTCTCCTGT 12061 TCCGACCCTG CCGCTTACCG GATACCTGTC CGCCTTTCTC CCTTCGGGAA GCGTGGCGCT 12121 TTCTCATAGC TCACGCTGTA GGTATCTCAG TTCGGTGTAG GTCGTTCGCT CCAAGCTGGG 12181 CTGTGTGCAC GAACCCCCCG TTCAGCCCGA CCGCTGCGCC TTATCCGGTA ACTATCGTCT 12241 TGAGTCCAAC CCGGTAAGAC ACGACTTATC GCCACTGGCA GCAGCCACTG GTAACAGGAT 12301 TAGCAGAGCG AGGTATGTAG GCGGTGCTAC AGAGTTCTTG AAGTGGTGGC CTAACTACGG 12361 CTACACTAGA AGGACAGTAT TTGGTATCTG CGCTCTGCTG AAGCCAGTTA CCTTCGGAAA 12421 AAGAGTTGGT AGCTCTTGAT CCGGCAAACA AACCACCGCT GGTAGCGGTG GTTTTTTTGT 12481 TTGCAAGCAG CAGATTACGC GCAGAAAAAA AGGATCTCAA GAAGATCCTT TGATCTTTTC 12541 TACGGGGTCT GACGCTCAGT GGAACGAAAA CTCACGTTAA GGGATTTTGG TCATGAGATT 12601 ATCAAAAAGG ATCTTCACCT AGATCCTTTT AAATTAAAAA TGAAGTTTTA AATCAATCTA 12661 AAGTATATAT GAGTAAACTT GGTCTGACAG TTACCAATGC TTAATCAGTG AGGCACCTAT 12721 CTCAGCGATC TGTCTATTTC GTTCATCCAT AGTTGCCTGA CTCCCCGTCG TGTAGATAAC 12781 TACGATACGG GAGGGCTTAC CATCTGGCCC CAGTGCTGCA ATGATACCGC GAGACCCACG 12841 CTCACCGGCT CCAGATTTAT CAGCAATAAA CCAGCCAGCC GGAAGGGCCG AGCGCAGAAG 12901 TGGTCCTGCA ACTTTATCCG CCTCCATCCA GTCTATTAAT TGTTGCCGGG AAGCTAGAGT 12961 AAGTAGTTCG CCAGTTAATA GTTTGCGCAA CGTTGTTGCC ATTGCTACAG GCATCGTGGT 13021 GTCACGCTCG TCGTTTGGTA TGGCTTCATT CAGCTCCGGT TCCCAACGAT CAAGGCGAGT 13081 TACATGATCC CCCATGTTGT GCAAAAAAGC GGTTAGCTCC TTCGGTCCTC CGATCGTTGT 13141 CAGAAGTAAG TTGGCCGCAG TGTTATCACT CATGGTTATG GCAGCACTGC ATAATTCTCT 13201 TACTGTCATG CCATCCGTAA GATGCTTTTC TGTGACTGGT GAGTACTCAA CCAAGTCATT 13261 CTGAGAATAG TGTATGCGGC GACCGAGTTG CTCTTGCCCG GCGTCAATAC GGGATAATAC 13321 CGCGCCACAT AGCAGAACTT TAAAAGTGCT CATCATTGGA AAACGTTCTT CGGGGCGAAA 13381 ACTCTCAAGG ATCTTACCGC TGTTGAGATC CAGTTCGATG TAACCCACTC GTGCACCCAA 13441 CTGATCTTCA GCATCTTTTA CTTTCACCAG CGTTTCTGGG TGAGCAAAAA CAGGAAGGCA 13501 AAATGCCGCA AAAAAGGGAA TAAGGGCGAC ACGGAAATGT TGAATACTCA TACTCTTCCT 13561 TTTTCAATAT TATTGAAGCA TTTATCAGGG TTATTGTCTC ATGAGCGGAT ACATATTTGA 13621 ATGTATTTAG AAAAATAAAC AAATAGGGGT TCCGCGCACA TTTCCCCGAA AAGTGCCACC 13681 TG //