LOCUS 90990_PB_tet_PHS 13093 bp ds-DNA circular 25-JUL-2013 DEFINITION . ACCESSION VERSION SOURCE . ORGANISM . COMMENT Insert from 90865 pORF-POU5F1(W01A119L12) 652 to 1582 COMMENT Backbone from 90946 PB-tet-PH-lox66FRT2 6253 to 4570 COMMENT ApEinfo:methylated:1 FEATURES Location/Qualifiers source join(4647..4714,4716..5119,5121..5435) /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6p21.31" /label=source:Homo sapiens /ApEinfo_fwdcolor=#ffffff /ApEinfo_revcolor=#ffffff /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1205..1459 /label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 gene join(4647..4714,4716..5119,5121..5435) /gene="POU5F1" /gene_synonym="Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4" /note="POU class 5 homeobox 1" /db_xref="GeneID:5460" /db_xref="HGNC:9221" /db_xref="MIM:164177" /label=POU5F1 /ApEinfo_fwdcolor=#ff0080 /ApEinfo_revcolor=#004080 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3331..3678 /label=polyA /ApEinfo_fwdcolor=#ff8080 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon join(4647..4714,4716..4881) /gene="POU5F1" /gene_synonym="Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4" /inference="alignment:Splign" /number=2b /label=POU5F1(1) /ApEinfo_label=POU5F1 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 602..619 /label=M13-fwd /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4571..4587 /label=attL1 /ApEinfo_fwdcolor=#ff0000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1460..1711 /label=mouse PGK promoter(1) /ApEinfo_label=mouse PGK promoter /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5492..5501 /label=attL2 /ApEinfo_fwdcolor=#ff0000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS 6225..6293 /label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind 618..645 /label=T7 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS join(4866..5119,5121..5435) /gene="POU5F1" /gene_synonym="Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4" /note="; isoform 2 is encoded by transcript variant 2; non-AUG (CUG) translation initiation codon; POU domain, class 5, transcription factor 1; octamer-binding transcription factor-3; POU-type homeodomain-containing DNA-binding protein; POU domain transcription factor OCT4; octamer-binding protein 3; octamer-binding protein 4; octamer-binding transcription factor 3" /codon_start=1 /product="POU domain, class 5, transcription factor 1 isoform 2" /protein_id="NP_976034.4" /db_xref="GI:291167755" /db_xref="CCDS:CCDS47398.1" /db_xref="GeneID:5460" /db_xref="HGNC:9221" /db_xref="MIM:164177" /translation="MGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNN ENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKD VVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSPHF TALYSSVPFPEGEAFPPVSVTTLGSPMHSN" /label=POU domain, class 5, transcription factor 1 isofor /ApEinfo_fwdcolor=#00ff00 /ApEinfo_revcolor=#ffff80 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 1732..2328 /label=Pac /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4944..4946 /gene="POU5F1" /gene_synonym="Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4" /note="start of isoform OCT4B-164, as described in PMID:19489092; Region: alternative AUG translation initiation codon" /label=POU5F1(2) /ApEinfo_label=POU5F1 /ApEinfo_fwdcolor=#80ff00 /ApEinfo_revcolor=#c0c0c0 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 5548..6071 /label=IRES /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature join(4647..4714,4716..5119,5121..5435) /label=GatewayCloneORF /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 4882..5012 /gene="POU5F1" /gene_synonym="Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4" /inference="alignment:Splign" /number=3 /label=POU5F1(3) /ApEinfo_label=POU5F1 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature complement(5502..5516) /label=AttR2 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(135..441) /label=F1 ori /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon join(5013..5119,5121..5171) /gene="POU5F1" /gene_synonym="Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4" /inference="alignment:Splign" /number=4 /label=POU5F1(4) /ApEinfo_label=POU5F1 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4446..4551 /label=mCMV promoter /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 exon 5172..5435 /gene="POU5F1" /gene_synonym="Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4" /inference="alignment:Splign" /number=5 /label=POU5F1(5) /ApEinfo_label=POU5F1 /ApEinfo_fwdcolor=pink /ApEinfo_revcolor=pink /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4160..4437 /label=8xTetO2 element /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature join(4644..5119,5121..5141) /label=Sequenced /ApEinfo_fwdcolor=#ff8040 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6073..10015 /label=b-geo /ApEinfo_fwdcolor=#800000 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(3..458) /label=M13 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4932..5435 /label=Sequenced(1) /ApEinfo_label=Sequenced /ApEinfo_fwdcolor=#ff8040 /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 3685..3926 /label=chicken 5'-HS4 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 6136..9161 /label=LacZ /ApEinfo_fwdcolor=#00ffff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 2335..3330 /label=DeltaTK /ApEinfo_fwdcolor=#0000ff /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10016..10322 /label=pA /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10440..10710 /label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 4563..4570 /label=AttR1 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(10900..10919) /label=T3 /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 primer_bind complement(10937..10957) /label=M13-rev /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(463..531) /label=LacZ alpha(1) /ApEinfo_label=LacZ alpha /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 rep_origin complement(11325..12007) /label=ColE1 origin /ApEinfo_fwdcolor=gray50 /ApEinfo_revcolor=gray50 /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 707..941 /label=PB 3'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_binding complement(10963..10985) /label=LacO /ApEinfo_fwdcolor=#6495ed /ApEinfo_revcolor=#6495ed /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 CDS complement(12105..12764) /label=AmpR /ApEinfo_fwdcolor=yellow /ApEinfo_revcolor=yellow /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 misc_feature 10711..10752 /label=PB 5'LTR(1) /ApEinfo_label=PB 5'LTR /ApEinfo_fwdcolor=cyan /ApEinfo_revcolor=green /ApEinfo_graphicformat=arrow_data {{0 1 2 0 0 -1} {} 0} width 5 offset 0 ORIGIN 1 GGAAATTGTA AACGTTAATA TTTTGTTAAA ATTCGCGTTA AATTTTTGTT AAATCAGCTC 61 ATTTTTTAAC CAATAGGCCG AAATCGGCAA AATCCCTTAT AAATCAAAAG AATAGACCGA 121 GATAGGGTTG AGTGTTGTTC CAGTTTGGAA CAAGAGTCCA CTATTAAAGA ACGTGGACTC 181 CAACGTCAAA GGGCGAAAAA CCGTCTATCA GGGCGATGGC CCACTACGTG AACCATCACC 241 CTAATCAAGT TTTTTGGGGT CGAGGTGCCG TAAAGCACTA AATCGGAACC CTAAAGGGAG 301 CCCCCGATTT AGAGCTTGAC GGGGAAAGCC GGCGAACGTG GCGAGAAAGG AAGGGAAGAA 361 AGCGAAAGGA GCGGGCGCTA GGGCGCTGGC AAGTGTAGCG GTCACGCTGC GCGTAACCAC 421 CACACCCGCC GCGCTTAATG CGCCGCTACA GGGCGCGTCG CGCCATTCGC CATTCAGGCT 481 GCGCAACTGT TGGGAAGGGC GATCGGTGCG GGCCTCTTCG CTATTACGCC AGCTGGCGAA 541 AGGGGGATGT GCTGCAAGGC GATTAAGTTG GGTAACGCCA GGGTTTTCCC AGTCACGACG 601 TTGTAAAACG ACGGCCAGTG AATTGTAATA CGACTCACTA TAGGGCGAAT TGGAGCTCGG 661 TATTCACGAC AGCAGGCTGA ATAATAAAAA AATTAGAAAC TATTATttaa ccctagaaag 721 ataatcatat tgtgacgtac gttaaagata atcatgcgta aaattgacgc atgtgtttta 781 tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt tattatattt 841 acacttacat actaataata aattcaacaa acaatttatt tatgtttatt tatttattaa 901 aaaaaaacaa aaactcaaaa tttcttctat aaagtaacaa aacttttaAA CATTCTCTCT 961 TTTACAAAAA TAAACTTATT TTGTACTTTA AAAACAGTCA TGTTGTATTA TAAAATAAGT 1021 AATTAGCTTA ACCTATACAT AATAGAAACA AATTATACTT ATTAGTCAGT CAGAAACAAC 1081 TTTGGCACAT ATCAATATTA TGCTCTCGTT ACTGGCGAAA GGGGGATGTG CTGCAAGGCG 1141 ATTAAGTTGG GTAACGCCAG GGTTTTCCCA GTCACGACGT TGTAAAACGA CGGCCAGTGA 1201 ATTCtaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc 1261 cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac 1321 cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc 1381 cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga 1441 agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt 1501 aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct 1561 gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg 1621 aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt 1681 ctcctcttcc tcatctccgg gcctttcgac cGATCATCAA GCTTGATCCT Catgaccgag 1741 tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccAgggccgt acgcaccctc 1801 gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgaTccgga ccgccacatc 1861 gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag 1921 gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa 1981 gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg 2041 gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg 2101 ttcctggcca ccgtcggcgt ctcgcccgac caccagggca agggtctggg cagcgccgtc 2161 gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacctcc 2221 gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag 2281 Gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgccgg atccATGCCC 2341 ACGCTACTGC GGGTTTATAT AGACGGTCCC CACGGGATGG GGAAAACCAC CACCACGCAA 2401 CTGCTGGTGG CCCTGGGTTC GCGCGACGAT ATCGTCTACG TACCCGAGCC GATGACTTAC 2461 TGGCGGGTGc TGGGGGCTTC CGAGACAATC GCGAACATCT ACACCACACA ACACCGCCTC 2521 GACCAGGGTG AGATATCGGC CGGGGACGCG GCGGTGGTAA TGACAAGCGC CCAGATAACA 2581 ATGGGCATGC CTTATGCCGT GACCGACGCC GTTCTGGCTC CTCATATCGG GGGGGAGGCT 2641 GGGAGCTCAC ATGCCCCGCC CCCGGCCCTC ACCCTCATCT TCGACCGCCA TCCCATCGCC 2701 GCCCTCCTGT GCTACCCGGC CGCGCGgTAC CTTATGGGCA GCATGACCCC CCAGGCCGTG 2761 CTGGCGTTCG TGGCCCTCAT CCCGCCGACC TTGCCCGGCA CcAACATCGT GcTTGGGGCC 2821 CTTCCGGAGG ACAGACACAT CGACCGCCTG GCCAAACGCC AGCGCCCCGG CGAGCGGCTg 2881 GACCTGGCTA TGCTGGCtGC GATTCGCCGC GTTTAcGGGC TaCTTGCCAA TACGGTGCGG 2941 TATCTGCAGt GCGGCGGGTC GTGGCGGGAG GAcTGGGGAC AGCTTTCGGG GaCGGCCGTG 3001 CCGCCCCAGG GTGCCGAGCC CCAGAGCAAC GCGGGCCCAC GACCCCATAT CGGGGACACG 3061 TTATTTACCC TGTTTCGGGC CCCCGAGTTG CTGGCCCCCA ACGGCGACCT GTATAACGTG 3121 TTTGCCTGGG CcTTGGACGT CTTGGCCAAA CGCCTCCGTT CCATGCACGT CTTTATCCTG 3181 GATTACGACC AATCGCCCGC CGGCTGCCGG GACGCCCTGC TGCAACTTAC CTCCGGGATG 3241 GTCCAGACCC ACGTCACCAC CCCCGGCTCC ATACCGACGA TATGCGACCT GGCGCGCACG 3301 TTTGCCCGGG AGATGGGGGA GGCTAACTGA gctctagctt atcgactcgc cgatagtgga 3361 aaccgacgcc ccagcactcg tccgagggca aaggaatagt cgagaaattg atgatctatt 3421 aaacaataaa gatgtccaca tggaagtttt tcctgtcata ctttgttaag aagggtgaga 3481 acagagtacc tacattttga atggaaggat tggagctacg ggggtggggg tggggtggga 3541 ttagataaat gcctgctctt tactgaaggc tctttactat tgctttatga taatgtttca 3601 tagttggata tcataattta aacaagcaaa accaaattaa gggccagctc attcctccca 3661 ctcatgatct atagatccTc tagaGAGCTC ACGGGGACAG CCCCCCCCCA AAGCCCCCAG 3721 GGATGTAATT ACGTCCCTCC CCCGCTAGGG GGCAGCAGCG AGCCGCCCGG GGCTCCGCTC 3781 CGGTCCGGCG CTCCCCCCGC ATCCCCGAGC CGGCAGCGTG CGGGGACAGC CCGGGCACGG 3841 GGAAGGTGGC ACGGGATCGC TTTCCTCTGA ACGCTTCTCG CTGCTCTTTG AGCCTGCAGA 3901 CACCTGGGGG ATACGGGGAA AAAGCTgtcg aCCTGCAGGC ATGCAAGCTT GGCGTAATCA 3961 TGGTCATAGC TGTTTCCTGT GTGAAATTGT TATCCGCTCA CAATTCCACA CAACATACGA 4021 GCCGGAAGCA TAAAGTGTAA AGCCTGGGGT GCCTAATGAG TGAGCTAACT CACATTAATT 4081 GCGTTGCGCT CACTGCCCGC TTTCCAGTCG GGAAACCTGT CGTGCCAGTA ACTCGAGGGA 4141 TCCAAGCTgg CCgcACGTCT CCCTATCAGT GATAGAGAAG TCGACACGTC TCGAGCTCCC 4201 TATCAGTGAT AGAGAAGGTA CGTCTAGAAC GTCTCCCTAT CAGTGATAGA GAAGTCGACA 4261 CGTCTCGAGC TCCCTATCAG TGATAGAGAA GGTACGTCTA GAACGTCTCC CTATCAGTGA 4321 TAGAGAAGTC GACACGTCTC GAGCTCCCTA TCAGTGATAG AGAAGGTACG TCTAGAACGT 4381 CTCCCTATCA GTGATAGAGA AGTCGACACG TCTCGAGCTC CCTATCAGTG ATAGAGAAGG 4441 TACCCCCTAT ATAAGCAGAG CTCGTTTAGT GAACCGTCAG ATCGCCTGGA GACGCCATCC 4501 ACGCTGTTTT GACCTCCATA GAAGACACCG GGACCGATCC AGCCTCCGCG GTGGCGGCCA 4561 TCACAAGTTT GTACAAAAAA GCAGGCTCCG CGGCCGCCCC CTTCACCGCT AGGGATAACA 4621 GGGTAATAGA AGGAGCCGCC ACCATGTTCT ACAGACTATT CCTTGGGGCC ACACGTAGGT 4681 TCTTGAATCC CGAATGGAAA GGGGAGATTG ATAAtTGGTG TGTTTATGTT CTTACAAGTC 4741 TTCTGCCTTT TAAAATCCAG TCCCAGGACA TCAAAGCTCT GCAGAAAGAA CTCGAGCAAT 4801 TTGCCAAGCT CCTGAAGCAG AAGAGGATCA CCCTGGGATA TACACAGGCC GATGTGGGGC 4861 TCACCCTGGG GGTTCTATTT GGGAAGGTAT TCAGCCAAAC GACCATCTGC CGCTTTGAGG 4921 CTCTGCAGCT TAGCTTCAAG AACATGTGTA AGCTGCGGCC CTTGCTGCAG AAGTGGGTGG 4981 AGGAAGCTGA CAACAATGAA AATCTTCAGG AGATATGCAA AGCAGAAACC CTCGTGCAGG 5041 CCCGAAAGAG AAAGCGAACC AGTATCGAGA ACCGAGTGAG AGGCAACCTG GAGAATTTGT 5101 TCCTGCAGTG CCCGAAACCg ACACTGCAGC AGATCAGCCA CATCGCCCAG CAGCTTGGGC 5161 TCGAGAAGGA TGTGGTCCGA GTGTGGTTCT GTAACCGGCG CCAGAAGGGC AAGCGATCAA 5221 GCAGCGACTA TGCACAACGA GAGGATTTTG AGGCTGCTGG GTCTCCTTTC TCAGGGGGAC 5281 CAGTGTCCTT TCCTCTGGCC CCAGGGCCCC ATTTTGGTAC CCCAGGCTAT GGGAGCCCTC 5341 ACTTCACTGC ACTGTACTCC TCGGTCCCTT TCCCTGAGGG GGAAGCCTTT CCCCCTGTCT 5401 CCGTCACCAC TCTGGGCTCT CCCATGCATT CAAACTGAGT TTCCTGTGAA CAATTGCTCC 5461 TCTCTTAAGG TAGCAAAGGG TGGGCGCGCC GACCCAGCTT TCTTGTACAA AGTGGTGATg 5521 gccGCTCTAG CTAGTCGATA AGCTAATTCC GCCCCCCCCC CCCCCCCCCC CTCACCcTCC 5581 CCCCCCCcta acgttactgg ccgaagccgc ttggaataag gccggtgagc gtttgtctat 5641 atgttatttt ccaccatatt gccgtctttt ggcaatgtga gggcccgaaa cctggccctg 5701 tcttcttgac gacgattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt 5761 tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaacaa cgtctgtagc 5821 gaccctttgc aggcagcgga accccccacc tggcgacatg gatagttgtg gaaagagtca 5881 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 5941 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 6001 aaaacgtcta ggccccccga accacgggga cgtggttttg gtttgaaaaa cacgatgata 6061 atatggccac aaccatggaa cagggggatc agcttaccat ggccaagatc cctcctaaga 6121 agaagcgcaa agtcgaggat cccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 6181 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 6241 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tggcgctttg 6301 cctggtttcc ggcaccagaa gcggtgccgg aaagctggct ggagtgcgat cttcctgagg 6361 ccgatactgt cgtcgtcccc tcaaactggc agatgcacgg ttacgatgcg cccatctaca 6421 ccaacgtaac ctatcccatt acggtcaatc cgccgtttgt tcccacggag aatccgacgg 6481 gttgttactc gctcacattt aatgttgatg aaagctggct acaggaaggc cagacgcgaa 6541 ttatttttga tggcgttaac tcggcgtttc atctgtggtg caacgggcgc tgggtcggtt 6601 acggccagga cagtcgtttg ccgtctgaat ttgacctgag cgcattttta cgcgccggag 6661 aaaaccgcct cgcggtgatg gtgctgcgtt ggagtgacgg cagttatctg gaagatcagg 6721 atatgtggcg gatgagcggc attttccgtg acgtctcgtt gctgcataaa ccgactacac 6781 aaatcagcga tttccatgtt gccactcgct ttaatgatga tttcagccgc gctgtactgg 6841 aggctgaagt tcagatgtgc ggcgagttgc gtgactacct acgggtaaca gtttctttat 6901 ggcagggtga aacgcaggtc gccagcggca ccgcgccttt cggcggtgaa attatcgatg 6961 agcgtggtgg ttatgccgat cgcgtcacac tacgtctgaa cgtcgaaaac ccgaaactgt 7021 ggagcgccga aatcccgaat ctctatcgtg cggtggttga actgcacacc gccgacggca 7081 cgctgattga agcagaagcc tgcgatgtcg gtttccgcga ggtgcggatt gaaaatggtc 7141 tgctgctgct gaacggcaag ccgttgctga ttcgaggcgt taaccgtcac gagcatcatc 7201 ctctgcatgg tcaggtcatg gatgagcaga cgatggtgca ggatatcctg ctgatgaagc 7261 agaacaactt taacgccgtg cgctgttcgc attatccgaa ccatccgctg tggtacacgc 7321 tgtgcgaccg ctacggcctg tatgtggtgg atgaagccaa tattgaaacc cacggcatgg 7381 tgccaatgaa tcgtctgacc gatgatccgc gctggctacc ggcgatgagc gaacgcgtaa 7441 cgcgaatggt gcagcgcgat cgtaatcacc cgagtgtgat catctggtcg ctggggaatg 7501 aatcaggcca cggcgctaat cacgacgcgc tgtatcgctg gatcaaatct gtcgatcctt 7561 cccgcccggt gcagtatgaa ggcggcggag ccgacaccac ggccaccgat attatttgcc 7621 cgatgtacgc gcgcgtggat gaagaccagc ccttcccggc tgtgccgaaa tggtccatca 7681 aaaaatggct ttcgctacct ggagagacgc gcccgctgat cctttgcgaa tacgcccacg 7741 cgatgggtaa cagtcttggc ggtttcgcta aatactggca ggcgtttcgt cagtatcccc 7801 gtttacaggg cggcttcgtc tgggactggg tggatcagtc gctgattaaa tatgatgaaa 7861 acggcaaccc gtggtcggct tacggcggtg attttggcga tacgccgaac gatcgccagt 7921 tctgtatgaa cggtctggtc tttgccgacc gcacgccgca tccagcgctg acggaagcaa 7981 aacaccagca gcagtttttc cagttccgtt tatccgggca aaccatcgaa gtgaccagcg 8041 aatacctgtt ccgtcatagc gataacgagc tcctgcactg gatggtggcg ctggatggta 8101 agccgctggc aagcggtgaa gtgcctctgg atgtcgctcc acaaggtaaa cagttgattg 8161 aactgcctga actaccgcag ccggagagcg ccgggcaact ctggctcaca gtacgcgtag 8221 tgcaaccgaa cgcgaccgca tggtcagaag ccgggcacat cagcgcctgg cagcagtggc 8281 gtctggcgga aaacctcagt gtgacgctcc ccgccgcgtc ccacgccatc ccgcatctga 8341 ccaccagcga aatggatttt tgcatcgagc tgggtaataa gcgttggcaa tttaaccgcc 8401 agtcaggctt tctttcacag atgtggattg gcgataaaaa acaactgctg acgccgctgc 8461 gcgatcagtt cacccgtgca ccgctggata acgacattgg cgtaagtgaa gcgacccgca 8521 ttgaccctaa cgcctgggtc gaacgctgga aggcggcggg ccattaccag gccgaagcag 8581 cgttgttgca gtgcacggca gatacacttg ctgatgcggt gctgattacg accgctcacg 8641 cgtggcagca tcaggggaaa accttattta tcagccggaa aacctaccgg attgatggta 8701 gtggtcaaat ggcgattacc gttgatgttg aagtggcgag cgatacaccg catccggcgc 8761 ggattggcct gaactgccag ctggcgcagg tagcagagcg ggtaaactgg ctcggattag 8821 ggccgcaaga aaactatccc gaccgcctta ctgccgcctg ttttgaccgc tgggatctgc 8881 cattgtcaga catgtatacc ccgtacgtct tcccgagcga aaacggtctg cgctgcggga 8941 cgcgcgaatt gaattatggc ccacaccagt ggcgcggcga cttccagttc aacatcagcc 9001 gctacagtca acagcaactg atggaaacca gccatcgcca tctgctgcac gcggaagaag 9061 gcacatggct gaatatcgac ggtttccata tggggattgg tggcgacgac tcctggagcc 9121 cgtcagtatc ggcggaattc cagctgagcg ccggtcgcta ccattaccag ttggtctggt 9181 gtcaggggat cccccgggct gcagccaata tgggatcggc cattgaacaa gatggattgc 9241 acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga 9301 caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt 9361 ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca gcgcggctat 9421 cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg 9481 gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg 9541 ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc 9601 cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga 9661 tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag 9721 ccgaactgtt cgccaggctc aaggcgcgca tgcccgacgg cgatgatctc gtcgtgaccc 9781 atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg 9841 actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata 9901 ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg 9961 ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc tgaggggatc 10021 aattctctag ggctcgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg 10081 tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct 10141 aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg 10201 gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg 10261 cggtgggctc tatggcttct gaggcggaaa gaaccagctg gggctcgatc ctctagagtc 10321 gaGGGCTGCA GGAATTCGAT ATCAAGCTCT AGCCAACAAG CTCGTCATCG CTTTGCAGAA 10381 GAGCAGAGAG GATATGCTCA TCGTCTAAAG AACTACCCAT TTTATTATAT ATTAGTCACg 10441 atatctataa caagaaaata tatatataat aagttatcac gtaagtagaa catgaaataa 10501 caatataatt atcgtatgag ttaaatctta aaagtcacgt aaaagataat catgcgtcat 10561 tttgactcac gcggtcgtta tagttcaaaa tcagtgacac ttaccgcatt gacaagcacg 10621 cctcacggga gctccaagcg gcgactgaga tgtcctaaat gcacagcgac ggattcgcgc 10681 tatttagaaa gagagagcaa tatttcaaga ATGCATgcgt caattttacg cagactatct 10741 ttctagggtt aaAtttAAAt GATTTGCGCT TTACTCGACC TAAACTTTAA ACACGTCATA 10801 GAATCTTCGT TTGACAAAAA CCACATTGTG GCCAAGCTGT GTGACGCGAC GCGCGCTAAA 10861 GAATGGCAAA CCAAGTCGCG CGAGGTACCC AGCTTTTGTT CCCTTTAGTG AGGGTTAATT 10921 CCGAGCTTGG CGTAATCATG GTCATAGCTG TTTCCTGTGT GAAATTGTTA TCCGCTCACA 10981 ATTCCACACA ACATACGAGC CGGAAGCATA AAGTGTAAAG CCTGGGGTGC CTAATGAGTG 11041 AGCTAACTCA CATTAATTGC GTTGCGCTCA CTGCCCGCTT TCCAGTCGGG AAACCTGTCG 11101 TGCCAGCTGC ATTAATGAAT CGGCCAACGC GCGGGGAGAG GCGGTTTGCG TATTGGGCGC 11161 TCTTCCGCTT CCTCGCTCAC TGACTCGCTG CGCTCGGTCG TTCGGCTGCG GCGAGCGGTA 11221 TCAGCTCACT CAAAGGCGGT AATACGGTTA TCCACAGAAT CAGGGGATAA CGCAGGAAAG 11281 AACATGTGAG CAAAAGGCCA GCAAAAGGCC AGGAACCGTA AAAAGGCCGC GTTGCTGGCG 11341 TTTTTCCATA GGCTCCGCCC CCCTGACGAG CATCACAAAA ATCGACGCTC AAGTCAGAGG 11401 TGGCGAAACC CGACAGGACT ATAAAGATAC CAGGCGTTTC CCCCTGGAAG CTCCCTCGTG 11461 CGCTCTCCTG TTCCGACCCT GCCGCTTACC GGATACCTGT CCGCCTTTCT CCCTTCGGGA 11521 AGCGTGGCGC TTTCTCATAG CTCACGCTGT AGGTATCTCA GTTCGGTGTA GGTCGTTCGC 11581 TCCAAGCTGG GCTGTGTGCA CGAACCCCCC GTTCAGCCCG ACCGCTGCGC CTTATCCGGT 11641 AACTATCGTC TTGAGTCCAA CCCGGTAAGA CACGACTTAT CGCCACTGGC AGCAGCCACT 11701 GGTAACAGGA TTAGCAGAGC GAGGTATGTA GGCGGTGCTA CAGAGTTCTT GAAGTGGTGG 11761 CCTAACTACG GCTACACTAG AAGGACAGTA TTTGGTATCT GCGCTCTGCT GAAGCCAGTT 11821 ACCTTCGGAA AAAGAGTTGG TAGCTCTTGA TCCGGCAAAC AAACCACCGC TGGTAGCGGT 11881 GGTTTTTTTG TTTGCAAGCA GCAGATTACG CGCAGAAAAA AAGGATCTCA AGAAGATCCT 11941 TTGATCTTTT CTACGGGGTC TGACGCTCAG TGGAACGAAA ACTCACGTTA AGGGATTTTG 12001 GTCATGAGAT TATCAAAAAG GATCTTCACC TAGATCCTTT TAAATTAAAA ATGAAGTTTT 12061 AAATCAATCT AAAGTATATA TGAGTAAACT TGGTCTGACA GTTACCAATG CTTAATCAGT 12121 GAGGCACCTA TCTCAGCGAT CTGTCTATTT CGTTCATCCA TAGTTGCCTG ACTCCCCGTC 12181 GTGTAGATAA CTACGATACG GGAGGGCTTA CCATCTGGCC CCAGTGCTGC AATGATACCG 12241 CGAGACCCAC GCTCACCGGC TCCAGATTTA TCAGCAATAA ACCAGCCAGC CGGAAGGGCC 12301 GAGCGCAGAA GTGGTCCTGC AACTTTATCC GCCTCCATCC AGTCTATTAA TTGTTGCCGG 12361 GAAGCTAGAG TAAGTAGTTC GCCAGTTAAT AGTTTGCGCA ACGTTGTTGC CATTGCTACA 12421 GGCATCGTGG TGTCACGCTC GTCGTTTGGT ATGGCTTCAT TCAGCTCCGG TTCCCAACGA 12481 TCAAGGCGAG TTACATGATC CCCCATGTTG TGCAAAAAAG CGGTTAGCTC CTTCGGTCCT 12541 CCGATCGTTG TCAGAAGTAA GTTGGCCGCA GTGTTATCAC TCATGGTTAT GGCAGCACTG 12601 CATAATTCTC TTACTGTCAT GCCATCCGTA AGATGCTTTT CTGTGACTGG TGAGTACTCA 12661 ACCAAGTCAT TCTGAGAATA GTGTATGCGG CGACCGAGTT GCTCTTGCCC GGCGTCAATA 12721 CGGGATAATA CCGCGCCACA TAGCAGAACT TTAAAAGTGC TCATCATTGG AAAACGTTCT 12781 TCGGGGCGAA AACTCTCAAG GATCTTACCG CTGTTGAGAT CCAGTTCGAT GTAACCCACT 12841 CGTGCACCCA ACTGATCTTC AGCATCTTTT ACTTTCACCA GCGTTTCTGG GTGAGCAAAA 12901 ACAGGAAGGC AAAATGCCGC AAAAAAGGGA ATAAGGGCGA CACGGAAATG TTGAATACTC 12961 ATACTCTTCC TTTTTCAATA TTATTGAAGC ATTTATCAGG GTTATTGTCT CATGAGCGGA 13021 TACATATTTG AATGTATTTA GAAAAATAAA CAAATAGGGG TTCCGCGCAC ATTTCCCCGA 13081 AAAGTGCCAC CTG //